Neidio i'r cynnwys

solute carrier family 6 member 4

Ni chefnogir cynnwys y dudalen mewn ieithoedd eraill.
Creu erthygl

This is an automatic view based on data from Wicidata.
There is not a complete article yet, but you can help creating one.

mammalian protein found in Homo sapiens

Adnoddau allanol

dynodwr Microsoft Academic
2778897192
2909985787
RefSeq protein ID
NP_001036[1]
Transporter Classification Database ID
2.A.22.1.1[2][3]
Ensembl protein ID
ENSP00000261707[4]
ENSP00000385822[5]
ENSP00000378298[6]
ENSP00000463172[7]
ENSP00000498537[8]
UniProt protein ID
P31645[9]
dynodwr Freebase
/m/02fm_d[10]
PDB structure ID
5I6X[11]
5I73[11]
5I75[11]
5I6Z[11]
5I71[11]
5I74[11]
OpenAlex ID
C2778897192[12]

enghraifft o'r canlynol

protein[9]

rhan o'r canlynol

Sodium:neurotransmitter symporter[13][14]
Sodium:neurotransmitter symporter superfamily[13]
Sodium:neurotransmitter symporter, serotonin, N-terminal domain, protein family[15]

found in taxon

Homo sapiens[9]

amgodiwyd gan

SLC6A4[9]

swyddogaeth moleciwlaidd

rhwymiadau cocên[16]

dull penderfynu: IEA

nitric-oxide synthase binding[16]

dull penderfynu: IEA

protein homodimerization activity[16]

dull penderfynu: IEA

myosin binding[16]

dull penderfynu: IEA

syntaxin-1 binding[16]

dull penderfynu: IEA

metal ion binding[17]

dull penderfynu: IEA

neurotransmitter:sodium symporter activity[18]

dull penderfynu: IEA

actin filament binding[19][16]

dull penderfynu: ISS, IEA

monoamine transmembrane transporter activity[20]

dull penderfynu: IDA

protein binding[21][22][23][24]

dull penderfynu: IPI

symporter activity[17]

dull penderfynu: IEA

serotonin:sodium symporter activity[25][26][27][28][29]

dull penderfynu: IDA, IEA, IMP, TAS

dopamine:sodium symporter activity[30]

dull penderfynu: IBA

serotonin:sodium symporter activity[31][32][33][34][35][36]

dull penderfynu: IBA, IDA, IEA, IMP, TAS

serotonin binding[37]

dull penderfynu: IBA

serotonin:sodium symporter activity[38][18][16][39][37]

dull penderfynu: IBA, IDA, IEA, TAS

rhan o'r gell

integral component of membrane[17][18]

dull penderfynu: IEA

cytosol[40]

dull penderfynu: IDA

endosome[17]

dull penderfynu: IEA

bilen[17]

dull penderfynu: IEA

integral component of plasma membrane[27][41][30]

dull penderfynu: IBA, IC, IEA

membrane raft[16][42]

dull penderfynu: IDA, IEA

neuron projection[16][37]

dull penderfynu: IBA, IEA

endosome membrane[17]

dull penderfynu: IEA

endomembrane system[17][16][43][44]

dull penderfynu: IDA, IEA

presynapse[45]

dull penderfynu: IEA

Cellbilen[25][46][28][47][48][49][50]

dull penderfynu: IDA, IEA, TAS

integral component of postsynaptic membrane[16]

dull penderfynu: IEA

integral component of presynaptic membrane[16]

dull penderfynu: IEA

serotonergic synapse[16]

dull penderfynu: IEA

Cellbilen[38][17][16][42][43][44][37]

dull penderfynu: IBA, IDA, IEA, TAS

integral component of plasma membrane[33][51]

dull penderfynu: IC, IEA

integral component of plasma membrane[18]

dull penderfynu: IEA

focal adhesion[19][16]

dull penderfynu: IEA, ISS

synapse[19][16]

dull penderfynu: IEA, ISS

proses fiolegol

cellular response to organic substance[16]

dull penderfynu: IEA

cellular response to retinoic acid[16]

dull penderfynu: IEA

response to estradiol[16]

dull penderfynu: IEA

cellular response to cGMP[16]

dull penderfynu: IEA

response to hypoxia[16]

dull penderfynu: IEA

negative regulation of neuron differentiation[16]

dull penderfynu: IEA

Alldafliad[16]

dull penderfynu: IEA

response to nutrient[16]

dull penderfynu: IEA

fasogyfyngiad[16]

dull penderfynu: IEA

negative regulation of cerebellar granule cell precursor proliferation[16]

dull penderfynu: IEA

Cof[16]

dull penderfynu: IEA

monoamine transport[20]

dull penderfynu: IDA

response to organic substance[16]

dull penderfynu: IEA

brain development[16]

dull penderfynu: IEA

positive regulation of gene expression[16]

dull penderfynu: IEA

positive regulation of cell cycle[16]

dull penderfynu: IEA

serotonin transport[34][40]

dull penderfynu: IDA, IEA

protein complex oligomerization[19][16]

dull penderfynu: ISS, IEA

Rhythm circadaidd[16]

dull penderfynu: IEA

transmembrane transport[52]

dull penderfynu: IEA

social behavior[53][16]

dull penderfynu: ISS, IEA

serotonin uptake[54][28][47][29][48][49][50]

dull penderfynu: IDA, IEA, IMP

neurotransmitter transport[17][18]

dull penderfynu: IEA

negative regulation of organ growth[53][16]

dull penderfynu: ISS, IEA

protein homooligomerization[16]

dull penderfynu: IEA

response to toxic substance[55]

dull penderfynu: IDA

negative regulation of synaptic transmission, dopaminergic[16]

dull penderfynu: IEA

brain morphogenesis[53][16]

dull penderfynu: ISS, IEA

positive regulation of serotonin secretion[16]

dull penderfynu: IEA

neurotransmitter biosynthetic process[38]

dull penderfynu: TAS

dopamine uptake involved in synaptic transmission[30]

dull penderfynu: IBA

regulation of thalamus size[56]

dull penderfynu: IMP

serotonin uptake[57][16][39][42][43][44][37]

dull penderfynu: IBA, IDA, IEA, IMP

serotonin transport[16]

dull penderfynu: IEA

adweithia'n ffisegol gyda

amitriptylin[58]

defnydd: enzyme inhibitor

amocsapin[59]

defnydd: enzyme inhibitor

atomocsetin[60]

defnydd: enzyme inhibitor

citalopram[61][62]

defnydd: enzyme inhibitor

clomipramin[63]

defnydd: enzyme inhibitor

dapoxetine[64]

defnydd: enzyme inhibitor

desipramin[65]

defnydd: enzyme inhibitor

desvenlafaxine[66]

defnydd: enzyme inhibitor

(S)-duloxetine[67]

defnydd: enzyme inhibitor

escitalopram[68]

defnydd: enzyme inhibitor

fflwocsetin[69]

defnydd: enzyme inhibitor

fflwfocsamin[70]

defnydd: enzyme inhibitor

imipramin[71]

defnydd: enzyme inhibitor

levomilnacipran[72]

defnydd: enzyme inhibitor

lofepramine[73]

defnydd: enzyme inhibitor

neffasodon[74]

defnydd: enzyme inhibitor

nortriptylin[75]

defnydd: enzyme inhibitor

parocsetin[76]

defnydd: enzyme inhibitor

ffenelsin[77]

defnydd: enzyme inhibitor

protriptylin[78]

defnydd: enzyme inhibitor

sertralin[79]

defnydd: enzyme inhibitor

(RS)-sibutramine[80]

defnydd: enzyme inhibitor

trimipramin[81]

defnydd: enzyme inhibitor

fenlaffacsin[82]

defnydd: enzyme inhibitor

vilazodone[83]

defnydd: enzyme inhibitor

vortioxetine[84]

defnydd: enzyme inhibitor

siprasidon[85]

defnydd: enzyme inhibitor

zotepine[86]

defnydd: enzyme inhibitor

Gene Atlas image

facilitates flow of

serotonin

cysyniad o'r un fath

http://purl.uniprot.org/uniprot/P31645[87]

yn cynnwys

Sodium:neurotransmitter symporter, serotonin, N-terminal[13]

categori Comin

Serotonin transporters

Cyfeiriadau

  1. ↑ NCBI Gene, 30 Mai 2020, 6532
  2. ↑ Transporter Classification database, 13 Mawrth 2020
  3. ↑ Transporter Classification database, 29 Ebrill 2020
  4. ↑ Ensembl Release 99, ENSP00000261707
  5. ↑ Ensembl Release 99, ENSP00000385822
  6. ↑ Ensembl Release 99, ENSP00000378298
  7. ↑ Ensembl Release 99, ENSP00000463172
  8. ↑ Ensembl Release 99, ENSP00000498537
  9. ↑ 9.0 9.1 9.2 9.3 UniProt, 13 Tachwedd 2019, P31645
  10. ↑ Freebase Data Dumps, 28 Hydref 2013
  11. ↑ 11.0 11.1 11.2 11.3 11.4 11.5 P31645, 9 Awst 2016, UniProt, Saesneg
  12. ↑ OpenAlex, 26 Ionawr 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  13. ↑ 13.0 13.1 13.2 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P31645
  14. ↑ 2.A.22.1.1, 2 Hydref 2019, hierarchical database ID heuristic
  15. ↑ inferred from protein domain or family
  16. ↑ 16.00 16.01 16.02 16.03 16.04 16.05 16.06 16.07 16.08 16.09 16.10 16.11 16.12 16.13 16.14 16.15 16.16 16.17 16.18 16.19 16.20 16.21 16.22 16.23 16.24 16.25 16.26 16.27 16.28 16.29 16.30 16.31 16.32 16.33 16.34 16.35 16.36 16.37 16.38 16.39 16.40 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9 Mai 2019, Ensembl, GOA
  17. ↑ 17.0 17.1 17.2 17.3 17.4 17.5 17.6 17.7 17.8 IEA, 9 Mai 2019, P31645, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  18. ↑ 18.0 18.1 18.2 18.3 18.4 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9 Mai 2019, InterPro, GOA
  19. ↑ 19.0 19.1 19.2 19.3 ISS, 9 Mai 2019, P31645, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  20. ↑ 20.0 20.1 IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9 Mai 2019, Mouse Genome Informatics, IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity, GOA
  21. ↑ IPI, 9 Mai 2019, P31645, Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  22. ↑ IPI, 9 Mai 2019, P31645, Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  23. ↑ IPI, 9 Mai 2019, P31645, Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  24. ↑ IPI, 9 Mai 2019, P31645, The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  25. ↑ 25.0 25.1 TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 16 Gorffennaf 2018, Reactome, GOA
  26. ↑ IMP, 16 Gorffennaf 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  27. ↑ 27.0 27.1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 16 Gorffennaf 2018, InterPro, GOA
  28. ↑ 28.0 28.1 28.2 IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 16 Gorffennaf 2018, Ensembl, GOA
  29. ↑ 29.0 29.1 IDA, 16 Gorffennaf 2018, P31645, Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  30. ↑ 30.0 30.1 30.2 IBA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 16 Gorffennaf 2018, GO Central, GOA
  31. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 1 Ionawr 2018, Reactome, GOA
  32. ↑ IMP, 1 Ionawr 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  33. ↑ 33.0 33.1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 1 Ionawr 2018, InterPro, GOA
  34. ↑ 34.0 34.1 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 1 Ionawr 2018, Ensembl, GOA
  35. ↑ IDA, 1 Ionawr 2018, P31645, Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  36. ↑ IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 1 Ionawr 2018, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
  37. ↑ 37.0 37.1 37.2 37.3 37.4 IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9 Mai 2019, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
  38. ↑ 38.0 38.1 38.2 TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9 Mai 2019, Reactome, GOA
  39. ↑ 39.0 39.1 IDA, 9 Mai 2019, P31645, Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  40. ↑ 40.0 40.1 IDA, 1 Ionawr 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  41. ↑ IC, 16 Gorffennaf 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  42. ↑ 42.0 42.1 42.2 IDA, 9 Mai 2019, P31645, Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  43. ↑ 43.0 43.1 43.2 IDA, 9 Mai 2019, P31645, Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  44. ↑ 44.0 44.1 44.2 IDA, 9 Mai 2019, P31645, Plasma serotonin levels and the platelet serotonin transporter, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  45. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 1 Ionawr 2018, Gene Ontology Consortium, GOA
  46. ↑ IEA, 16 Gorffennaf 2018, P31645, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  47. ↑ 47.0 47.1 IDA, 16 Gorffennaf 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  48. ↑ 48.0 48.1 IDA, 16 Gorffennaf 2018, P31645, Plasma serotonin levels and the platelet serotonin transporter, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  49. ↑ 49.0 49.1 IDA, 16 Gorffennaf 2018, P31645, Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  50. ↑ 50.0 50.1 IDA, 16 Gorffennaf 2018, P31645, Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, UniProt
  51. ↑ IC, 1 Ionawr 2018, P31645, Retracted: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  52. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9 Mai 2019, Gene Ontology Consortium, GOA
  53. ↑ 53.0 53.1 53.2 ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9 Mai 2019, British Heart Foundation, GOA
  54. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P31645&geneProductId=UniProtKB:P31645, 16 Gorffennaf 2018, Community Assessment of Community Annotation with Ontologies, Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization, GOA
  55. ↑ IDA, 9 Mai 2019, P31645, Differential expression of intestinal membrane transporters in cholera patients, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  56. ↑ IMP, 9 Mai 2019, P31645, Major depression, 5HTTLPR genotype, suicide and antidepressant influences on thalamic volume, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, UniProt
  57. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P31645, 9 Mai 2019, Community Assessment of Community Annotation with Ontologies, Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization, GOA
  58. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 200, Saesneg
  59. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 201, Saesneg
  60. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7118, Saesneg
  61. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7547, Saesneg
  62. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 4621, Saesneg
  63. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 2398, Saesneg
  64. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7901, Saesneg
  65. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 2399, Saesneg
  66. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7158, Saesneg
  67. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 202, Saesneg
  68. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7177, Saesneg
  69. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 203, Saesneg
  70. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7189, Saesneg
  71. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 357, Saesneg
  72. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7435, Saesneg
  73. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7551, Saesneg
  74. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7247, Saesneg
  75. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 2404, Saesneg
  76. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 4790, Saesneg
  77. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7266, Saesneg
  78. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7285, Saesneg
  79. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 4798, Saesneg
  80. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 2586, Saesneg
  81. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7317, Saesneg
  82. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7321, Saesneg
  83. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7427, Saesneg
  84. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 7351, Saesneg
  85. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 59, Saesneg
  86. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 Awst 2016, 103, Saesneg
  87. ↑ Identifiers.org
Wedi dod o "https://cy.wikipedia.org/wiki/Arbennig:Am_y_Pwnc/Q410142"