WWP1

WWP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ND7, 5HPS, 5HPT
Dynodwyr
Cyfenwau	WWP1, AIP5, Tiul1, hSDRP1, WW domain containing E3 ubiquitin protein ligase 1
Dynodwyr allanol	OMIM: 602307 HomoloGene: 21385 GeneCards: WWP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • GO:0050372 ubiquitin-protein transferase activity • transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cydrannau o'r gell • ubiquitin ligase complex • cytosol • Cellbilen • extracellular exosome • bilen • cnewyllyn cell • cytoplasm Prosesau biolegol • viral entry into host cell • central nervous system development • cludo transmembrane rhwng ïonau • GO:0022415 viral process • GO:0045996 negative regulation of transcription, DNA-templated • protein ubiquitination • GO:0072468 signal transduction • ubiquitin-dependent protein catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • protein polyubiquitination • GO:1903364 positive regulation of protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11059	n/a
Ensembl	ENSG00000123124	n/a
UniProt	Q9H0M0	n/a
RefSeq (mRNA)	NM_007013	n/a
RefSeq (protein)	NP_008944	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn WWP1 yw WWP1 a elwir hefyd yn NEDD4-like E3 ubiquitin-protein ligase WWP1 ac WW domain containing E3 ubiquitin protein ligase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn WWP1.

• AIP5
• Tiul1
• hSDRP1

Llyfryddiaeth

• "WWP1 gene is a potential molecular target of human oral cancer. ". Oral Surg Oral Med Oral Pathol Oral Radiol. 2013. PMID 23849376.
• "The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis. ". Bone. 2012. PMID 22266093.
• "Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress. ". J Virol. 2017. PMID 28768865.
• "Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase. ". J Biol Chem. 2017. PMID 28461335.
• "Overexpression of WWP1 promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma.". Oncotarget. 2015. PMID 26506518.