TP53BP1

TP53BP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 2LVM, 2MWO, 2MWP, 3LGF, 3LGL, 3LH0, 4CRI, 4RG2, 4X34, 5ECG
Dynodwyr
Cyfenwau	TP53BP1, 53BP1, p202, p53BP1, TP53, TDRD30, tumor protein p53 binding protein 1
Dynodwyr allanol	OMIM: 605230 HomoloGene: 4137 GeneCards: TP53BP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001104 transcription coregulator activity • p53 binding • GO:0001948, GO:0016582 protein binding • ubiquitin modification-dependent histone binding • damaged DNA binding • methylated histone binding • telomeric DNA binding • sequence-specific DNA binding • GO:0031493 histone binding Cydrannau o'r gell • cytoplasm • nucleoplasm • Cromosom • telomere • chromosome, centromeric region • kinetochore • nuclear body • cnewyllyn cell • replication fork • site of double-strand break • DNA repair complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • cellular response to X-ray • DNA damage checkpoint signaling • positive regulation of DNA-binding transcription factor activity • transcription, DNA-templated • cellular response to DNA damage stimulus • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0100026 DNA repair • protein homooligomerization • double-strand break repair via nonhomologous end joining • positive regulation of isotype switching • negative regulation of double-strand break repair via homologous recombination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7158	n/a
Ensembl	ENSG00000067369	n/a
UniProt	Q12888	n/a
RefSeq (mRNA)	NM_001141979 NM_001141980 NM_005657 NM_001355001	n/a
RefSeq (protein)	NP_001135451 NP_001135452 NP_005648 NP_001341930	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TP53BP1 yw TP53BP1 a elwir hefyd yn Tumor suppressor p53-binding protein 1 a Tumor protein p53 binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q15.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TP53BP1.

• TP53
• p202
• 53BP1
• TDRD30
• p53BP1

Llyfryddiaeth

• "The structural basis of modified nucleosome recognition by 53BP1. ". Nature. 2016. PMID 27462807.
• "53BP1 fosters fidelity of homology-directed DNA repair. ". Nat Struct Mol Biol. 2016. PMID 27348077.
• "Regulatory cross-talk determines the cellular levels of 53BP1 protein, a critical factor in DNA repair. ". J Biol Chem. 2017. PMID 28255090.
• "Reciprocal Regulation between 53BP1 and the Anaphase-Promoting Complex/Cyclosome Is Required for Genomic Stability during Mitotic Stress. ". Cell Rep. 2017. PMID 28228263.
• "Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer.". Int J Oncol. 2016. PMID 27499037.