TNFSF10

TNFSF10
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1D0G, 1D2Q, 1D4V, 1DG6, 1DU3, 4N90
Dynodwyr
Cyfenwau	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL, TNLG6A, tumor necrosis factor superfamily member 10, TNF superfamily member 10
Dynodwyr allanol	OMIM: 603598 HomoloGene: 2824 GeneCards: TNFSF10
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • metal ion binding • GO:0001948, GO:0016582 protein binding • tumor necrosis factor receptor superfamily binding • tumor necrosis factor receptor binding • signaling receptor binding • zinc ion binding • identical protein binding • TRAIL binding Cydrannau o'r gell • integral component of membrane • bilen • integral component of plasma membrane • extracellular region • extracellular exosome • extracellular space • Cellbilen Prosesau biolegol • activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • cell-cell signaling • cell surface receptor signaling pathway • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of release of cytochrome c from mitochondria • positive regulation of extrinsic apoptotic signaling pathway • regulation of extrinsic apoptotic signaling pathway via death domain receptors • activation of cysteine-type endopeptidase activity involved in apoptotic process • GO:0072468 signal transduction • GO:0097285 apoptotic process • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of apoptotic process • male gonad development • response to insulin • regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8743	n/a
Ensembl	ENSG00000121858	n/a
UniProt	P50591	n/a
RefSeq (mRNA)	NM_001190942 NM_001190943 NM_003810	n/a
RefSeq (protein)	NP_001177871 NP_001177872 NP_003801	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNFSF10 yw TNFSF10 a elwir hefyd yn TNF superfamily member 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q26.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNFSF10.

• TL2
• APO2L
• CD253
• TRAIL
• Apo-2L
• TNLG6A

Llyfryddiaeth

• "TRAIL in CD8+ T cells from patients with severe aplastic anemia. ". Int J Hematol. 2017. PMID 28631177.
• "Association between thyroid hormones and TRAIL. ". Clin Biochem. 2017. PMID 28551332.
• "TRAIL (TNF-related apoptosis-inducing ligand) inhibits human adipocyte differentiation via caspase-mediated downregulation of adipogenic transcription factors. ". Cell Death Dis. 2016. PMID 27735943.
• "A -1573T>C SNP within the human TRAIL promoter determines TRAIL expression and HCC tumor progression. ". Cancer Med. 2016. PMID 27580702.
• "TRAIL gene expression analysis in multiple sclerosis patients.". Hum Antibodies. 2016. PMID 27472871.