TERF2IP

TERF2IP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FEX, 3K6G, 4RQI
Dynodwyr
Cyfenwau	TERF2IP, DRIP5, RAP1, TERF2 interacting protein
Dynodwyr allanol	OMIM: 605061 HomoloGene: 10357 GeneCards: TERF2IP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • telomeric DNA binding • GO:0001948, GO:0016582 protein binding • G-rich strand telomeric DNA binding • phosphatase binding Cydrannau o'r gell • nuclear telomere cap complex • nuclear envelope • Cromosom • shelterin complex • telomere • nuclear chromosome • Mre11 complex • cnewyllyn cell • nucleoplasm • cytosol • nuclear body • cytoplasm Prosesau biolegol • negative regulation of DNA recombination at telomere • telomere maintenance via telomerase • protection from non-homologous end joining at telomere • regulation of double-strand break repair via homologous recombination • transcription, DNA-templated • positive regulation of peptidyl-serine phosphorylation • protein localization to chromosome, telomeric region • positive regulation of protein acetylation • telomere maintenance via telomere lengthening • positive regulation of NF-kappaB transcription factor activity • positive regulation of I-kappaB kinase/NF-kappaB signaling • telomere maintenance • telomere capping • GO:0033128 negative regulation of protein phosphorylation • GO:0009373 regulation of transcription, DNA-templated • regulation of telomere maintenance • negative regulation of telomere maintenance • positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	54386	n/a
Ensembl	ENSG00000166848	n/a
UniProt	Q9NYB0	n/a
RefSeq (mRNA)	NM_018975	n/a
RefSeq (protein)	NP_061848	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TERF2IP yw TERF2IP a elwir hefyd yn Telomeric repeat-binding factor 2-interacting protein 1 a TERF2 interacting protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TERF2IP.

• RAP1
• DRIP5

Llyfryddiaeth

• "NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains. ". J Mol Biol. 2001. PMID 11545594.
• "Basic domain of telomere guardian TRF2 reduces D-loop unwinding whereas Rap1 restores it. ". Nucleic Acids Res. 2017. PMID 28981702.
• "TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation. ". Cell Rep. 2014. PMID 25453752.
• "Quantitative imaging of focal adhesion dynamics and their regulation by HGF and Rap1 signaling. ". Exp Cell Res. 2015. PMID 25447308.
• "Downregulation of Rap1 promotes 5-fluorouracil-induced apoptosis in hepatocellular carcinoma cell line HepG2.". Oncol Rep. 2014. PMID 24549317.