SIRPA

SIRPA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2JJS, 2JJT, 2UV3, 2WNG, 4CMM
Dynodwyr
Cyfenwau	SIRPA, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP, Signal-regulatory protein alpha, signal regulatory protein alpha
Dynodwyr allanol	OMIM: 602461 HomoloGene: 7246 GeneCards: SIRPA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • SH3 domain binding • protein phosphatase binding • GO:0005083 GTPase regulator activity • protein binding involved in heterotypic cell-cell adhesion • cell-cell adhesion mediator activity • protein antigen binding • protein tyrosine kinase binding Cydrannau o'r gell • integral component of membrane • Cellbilen • extracellular exosome • bilen • tertiary granule membrane • ficolin-1-rich granule membrane • integral component of plasma membrane • cell surface Prosesau biolegol • cell adhesion • leukocyte migration • neutrophil degranulation • GO:0033128 negative regulation of protein phosphorylation • regulation of gene expression • cell migration • positive regulation of cell-cell adhesion • regulation of interferon-gamma production • regulation of interleukin-1 beta production • regulation of interleukin-6 production • regulation of tumor necrosis factor production • negative regulation of interferon-beta production • negative regulation of interleukin-6 production • negative regulation of tumor necrosis factor production • heterotypic cell-cell adhesion • monocyte extravasation • negative regulation of nitric oxide biosynthetic process • regulation of nitric oxide biosynthetic process • negative regulation of JNK cascade • negative regulation of inflammatory response • negative regulation of phagocytosis • positive regulation of phagocytosis • GO:0048552 regulation of catalytic activity • positive regulation of T cell activation • cellular response to hydrogen peroxide • negative regulation of ERK1 and ERK2 cascade • cellular response to lipopolysaccharide • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to interleukin-12 • negative regulation of macrophage inflammatory protein 1 alpha production • negative regulation of chemokine (C-C motif) ligand 5 production • cell-cell adhesion • negative regulation of cytokine production involved in inflammatory response • negative regulation of I-kappaB phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	140885	n/a
Ensembl	ENSG00000198053	n/a
UniProt	P78324	n/a
RefSeq (mRNA)	NM_001040022 NM_001040023 NM_080792 NM_001330728	n/a
RefSeq (protein)	NP_001035111 NP_001035112 NP_001317657 NP_542970	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SIRPA yw SIRPA a elwir hefyd yn Signal regulatory protein alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20p13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SIRPA.

• BIT
• MFR
• P84
• SIRP
• MYD-1
• SHPS1
• CD172A
• PTPNS1

Llyfryddiaeth

• "Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil accumulation in inflammation. ". J Innate Immun. 2014. PMID 24516072.
• "Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state. ". Nat Commun. 2013. PMID 24026300.
• "TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets. ". PLoS One. 2017. PMID 29084248.
• "Cleavage of Signal Regulatory Protein α (SIRPα) Enhances Inflammatory Signaling. ". J Biol Chem. 2015. PMID 26534964.
• "Hepatitis E virus infection activates signal regulator protein α to down-regulate type I interferon.". Immunol Res. 2016. PMID 26492885.