SETD2

SETD2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2A7O, 2MDC, 2MDI, 2MDJ, 4FMU, 4H12
Dynodwyr
Cyfenwau	SETD2, HBP231, HIF-1, HIP-1, HYPB, KMT3A, SET2, p231HBP, HSPC069, LLS, SET domain containing 2
Dynodwyr allanol	OMIM: 612778 HomoloGene: 56493 GeneCards: SETD2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • GO:0001948, GO:0016582 protein binding • histone-lysine N-methyltransferase activity • protein-lysine N-methyltransferase activity • alpha-tubulin binding • histone methyltransferase activity (H3-K36 specific) • metal ion binding Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • Cromosom Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • histone H3-K36 dimethylation • regulation of mRNA export from nucleus • embryonic organ development • stem cell development • embryonic placenta morphogenesis • transcription elongation from RNA polymerase II promoter • coronary vasculature morphogenesis • cell migration involved in vasculogenesis • morphogenesis of a branching structure • transcription, DNA-templated • mesoderm morphogenesis • vasculogenesis • histone H3-K36 methylation • methylation • neural tube closure • GO:0016584, GO:0001207, GO:0042766, GO:0001208, GO:0060303 nucleosome organization • angiogenesis • pericardium development • regulation of gene expression • histone H3-K36 trimethylation • embryonic cranial skeleton morphogenesis • DNA mismatch repair • histone lysine methylation • forebrain development • regulation of double-strand break repair via homologous recombination • peptidyl-lysine trimethylation • peptidyl-lysine monomethylation • regulation of cytokinesis • positive regulation of interferon-alpha production • response to type I interferon • endodermal cell differentiation • stem cell differentiation • microtubule cytoskeleton organization involved in mitosis • regulation of protein localization to chromatin • immune system process • GO:0100026 DNA repair • cellular response to DNA damage stimulus • multicellular organism development • cell differentiation • innate immune response • defense response to virus • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	29072	n/a
Ensembl	ENSG00000181555	n/a
UniProt	Q9BYW2	n/a
RefSeq (mRNA)	NM_012271 NM_014159 NM_001349370	n/a
RefSeq (protein)	NP_054878 NP_001336299	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SETD2 yw SETD2 a elwir hefyd yn SET domain containing 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3p21.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SETD2.

• LLS
• HYPB
• SET2
• HIF-1
• HIP-1
• KMT3A
• HBP231
• HSPC069
• p231HBP

Llyfryddiaeth

• "Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma. ". Oncotarget. 2016. PMID 26646321.
• "SETD2 histone modifier loss in aggressive GI stromal tumours. ". Gut. 2016. PMID 26338826.
• "A New Chromatin-Cytoskeleton Link in Cancer. ". Mol Cancer Res. 2016. PMID 27528705.
• "Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma. ". Neoplasia. 2016. PMID 27292023.
• "Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.". Leukemia. 2016. PMID 27282254.