NUP214

NUP214
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2OIT, 3FHC, 3FMO, 3FMP, 5DIS
Dynodwyr
Cyfenwau	NUP214, CAIN, CAN, D9S46E, N214, p250, nucleoporin 214kDa, nucleoporin 214, IIAE9
Dynodwyr allanol	OMIM: 114350 HomoloGene: 38008 GeneCards: NUP214
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nuclear export signal receptor activity • GO:0001948, GO:0016582 protein binding • nuclear localization sequence binding • GO:0005487 structural constituent of nuclear pore Cydrannau o'r gell • cytosol • intracellular membrane-bounded organelle • focal adhesion • nucleoplasm • cnewyllyn cell • cytoplasmic side of nuclear pore • nuclear pore nuclear basket • nuclear pore central transport channel • nuclear pore • nuclear envelope • host cell Prosesau biolegol • mRNA transport • regulation of mRNA stability • regulation of cell cycle • protein export from nucleus • protein transport • GO:0022415 viral process • protein import into nucleus • RNA export from nucleus • mRNA export from nucleus • regulation of nucleocytoplasmic transport • GO:0007067 Mitosis • regulation of glycolytic process • tRNA export from nucleus • protein sumoylation • viral transcription • GO:1905616 regulation of gene silencing by miRNA • GO:0046795 intracellular transport of virus • regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8021	n/a
Ensembl	ENSG00000126883	n/a
UniProt	P35658	n/a
RefSeq (mRNA)	NM_005085 NM_001318324 NM_001318325	n/a
RefSeq (protein)	NP_001305253 NP_001305254 NP_005076	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NUP214 yw NUP214 a elwir hefyd yn Nuclear pore complex protein Nup214 a Nucleoporin 214 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NUP214.

• CAN
• CAIN

Llyfryddiaeth

• "Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia. ". Leukemia. 2009. PMID 18923437.
• "Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN. ". Proc Natl Acad Sci U S A. 2007. PMID 17264208.
• "Validation-based insertional mutagenesis for identification of Nup214 as a host factor for EV71 replication in RD cells. ". Biochem Biophys Res Commun. 2013. PMID 23831628.
• "Assessing the value of CAN-gene mutations using MALDI-TOF MS. ". J Cancer Res Clin Oncol. 2011. PMID 21691751.
• "NUP214-ABL1 positive T-cell acute lymphoblastic leukemia patient shows an initial favorable response to imatinib therapy post relapse.". Leuk Res. 2011. PMID 21489623.