NUMB

NUMB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WJ1
Dynodwyr
Cyfenwau	NUMB, C14orf41, S171, c14_5527, endocytic adaptor protein, NUMB endocytic adaptor protein
Dynodwyr allanol	OMIM: 603728 HomoloGene: 2775 GeneCards: NUMB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • beta-catenin binding • GO:0001948, GO:0016582 protein binding • alpha-catenin binding • cadherin binding Cydrannau o'r gell • cytoplasm • bilen • focal adhesion • Cellbilen • apical part of cell • basolateral plasma membrane • early endosome • extrinsic component of plasma membrane • cnewyllyn cell • clathrin-coated vesicle • GO:0016023 cytoplasmic vesicle • glutamatergic synapse Prosesau biolegol • neuroblast division in subventricular zone • lateral ventricle development • axonogenesis • positive regulation of cell migration • nervous system development • multicellular organism development • positive regulation of neurogenesis • negative regulation of protein localization to plasma membrane • neuroblast proliferation • lung epithelial cell differentiation • positive regulation of polarized epithelial cell differentiation • forebrain development • adherens junction organization • negative regulation of Notch signaling pathway • regulation of postsynaptic neurotransmitter receptor internalization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8650	n/a
Ensembl	ENSG00000133961	n/a
UniProt	P49757	n/a
RefSeq (mRNA)	NM_001005743 NM_001005744 NM_001005745 NM_003744 NM_001320114	n/a
RefSeq (protein)	NP_001005743 NP_001005744 NP_001005745 NP_001307043 NP_003735	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NUMB yw NUMB a elwir hefyd yn NUMB, endocytic adaptor protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q24.2-q24.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NUMB.

• S171
• C14orf41
• c14_5527

Llyfryddiaeth

• "Human NUMB6 Induces Epithelial-Mesenchymal Transition and Enhances Breast Cancer Cells Migration and Invasion. ". J Cell Biochem. 2017. PMID 27302072.
• "Regulation of Numb isoform expression by activated ERK signaling. ". Oncogene. 2016. PMID 27041567.
• "Numb positively regulates autophagic flux via regulating lysosomal function. ". Biochem Biophys Res Commun. 2017. PMID 28720501.
• "Pre-clinical validation of a selective anti-cancer stem cell therapy for Numb-deficient human breast cancers. ". EMBO Mol Med. 2017. PMID 28298340.
• "Numb Gene Enhances Radiation Sensitivity of Nonsmall Cell Lung Cancer Stem Cells.". Cancer Biother Radiopharm. 2016. PMID 27310305.