NONO

NONO
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3SDE
Dynodwyr
Cyfenwau	NONO, NMT55, NRB54, P54, P54NRB, PPP1R114, MRXS34, non-POU domain containing, octamer-binding, non-POU domain containing octamer binding
Dynodwyr allanol	OMIM: 300084 HomoloGene: 7212 GeneCards: NONO
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • chromatin binding • GO:0000975 transcription cis-regulatory region binding • GO:0001948, GO:0016582 protein binding • identical protein binding • nucleic acid binding • RNA binding Cydrannau o'r gell • paraspeckles • nuclear speck • bilen • nuclear matrix • nucleoplasm • RNA polymerase II transcription regulator complex • nucleolus • cnewyllyn cell Prosesau biolegol • mRNA splicing, via spliceosome • DNA recombination • GO:0009373 regulation of transcription, DNA-templated • proses rythmig • mRNA processing • transcription, DNA-templated • cellular response to DNA damage stimulus • regulation of circadian rhythm • Rhythm circadaidd • RNA splicing • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • GO:0100026 DNA repair • activation of innate immune response • immune system process • innate immune response Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4841	n/a
Ensembl	ENSG00000147140	n/a
UniProt	Q15233	n/a
RefSeq (mRNA)	NM_007363 NM_001145408 NM_001145409 NM_001145410	n/a
RefSeq (protein)	NP_001138880 NP_001138881 NP_001138882 NP_031389	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NONO yw NONO a elwir hefyd yn Non-POU domain containing octamer binding a Non-POU domain-containing octamer-binding protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NONO.

• P54
• NMT55
• NRB54
• MRXS34
• P54NRB
• PPP1R114

Llyfryddiaeth

• "Intellectual disability and non-compaction cardiomyopathy with a de novo NONO mutation identified by exome sequencing. ". Eur J Hum Genet. 2016. PMID 27329731.
• "A crystallographic study of human NONO (p54(nrb)): overcoming pathological problems with purification, data collection and noncrystallographic symmetry. ". Acta Crystallogr D Struct Biol. 2016. PMID 27303796.
• "Knockdown of p54nrb inhibits migration, invasion and TNF-α release of human acute monocytic leukemia THP1 cells. ". Oncol Rep. 2016. PMID 27108701.
• "p54(nrb)/NONO regulates lipid metabolism and breast cancer growth through SREBP-1A. ". Oncogene. 2016. PMID 26148231.
• "Characterization of DNA binding and pairing activities associated with the native SFPQ·NONO DNA repair protein complex.". Biochem Biophys Res Commun. 2015. PMID 25998385.