NFAT5

NFAT5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IMH
Dynodwyr
Cyfenwau	NFAT5, NF-AT5, NFATL1, NFATZ, OREBP, TONEBP, nuclear factor of activated T-cells 5, tonicity-responsive, nuclear factor of activated T-cells 5, nuclear factor of activated T cells 5
Dynodwyr allanol	OMIM: 604708 HomoloGene: 4811 GeneCards: NFAT5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • chromatin binding • transcription factor binding Cydrannau o'r gell • cnewyllyn cell • nucleoplasm • cytoplasm • cytosol • transcription regulator complex Prosesau biolegol • regulation of calcineurin-NFAT signaling cascade • GO:0032617 cytokine production • GO:1901313 positive regulation of gene expression • Ysgarthu • GO:0009373 regulation of transcription, DNA-templated • transcription by RNA polymerase II • transcription, DNA-templated • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • calcineurin-NFAT signaling cascade • response to osmotic stress • cellular response to cytokine stimulus • positive regulation of NIK/NF-kappaB signaling • positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10725	n/a
Ensembl	ENSG00000102908	n/a
UniProt	O94916	n/a
RefSeq (mRNA)	NM_001113178 NM_006599 NM_138713 NM_138714 NM_173214 NM_173215 NM_001367709	n/a
RefSeq (protein)	NP_001106649 NP_006590 NP_619727 NP_619728 NP_775321 NP_775322 NP_001354638	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn NFAT5 yw NFAT5 a elwir hefyd yn Nuclear factor of-activated T-cells 5 a Nuclear factor of activated T-cells 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NFAT5.

• NFATZ
• OREBP
• NF-AT5
• NFATL1
• TONEBP

Llyfryddiaeth

• "The potential role of NFAT5 and osmolarity in peritoneal injury. ". Biomed Res Int. 2015. PMID 26495302.
• "NFAT5 Is Up-Regulated by Hypoxia: Possible Implications in Preeclampsia and Intrauterine Growth Restriction. ". Biol Reprod. 2015. PMID 25995271.
• "Involvement of TonEBP/NFAT5 in osmoadaptative response of human retinal pigmented epithelial cells to hyperosmolar stress. ". Mol Vis. 2016. PMID 26912969.
• "Peptide affinity analysis of proteins that bind to an unstructured NH2-terminal region of the osmoprotective transcription factor NFAT5. ". Physiol Genomics. 2016. PMID 26757802.
• "Transcriptomic and genetic studies identify NFAT5 as a candidate gene for cocaine dependence.". Transl Psychiatry. 2015. PMID 26506053.