ISG20

ISG20
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WLJ
Dynodwyr
Cyfenwau	ISG20, CD25, HEM45, interferon stimulated exonuclease gene 20kDa, interferon stimulated exonuclease gene 20
Dynodwyr allanol	OMIM: 604533 HomoloGene: 31081 GeneCards: ISG20
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • 3'-5'-exoribonuclease activity • single-stranded DNA 3'-5' exodeoxyribonuclease activity • exoribonuclease II activity • metal ion binding • U3 snoRNA binding • U2 snRNA binding • RNA binding • nucleic acid binding • U1 snRNA binding • nuclease activity • exonuclease activity • hydrolase activity Cydrannau o'r gell • cytoplasm • Cajal body • PML body • nucleoplasm • nucleolus • cnewyllyn cell Prosesau biolegol • immune system process • response to virus • RNA catabolic process • negative regulation of viral genome replication • DNA catabolic process, exonucleolytic • defense response to virus • type I interferon signaling pathway • rRNA processing • innate immune response • cell population proliferation • RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3669	n/a
Ensembl	ENSG00000172183	n/a
UniProt	Q96AZ6	n/a
RefSeq (mRNA)	NM_001303233 NM_001303234 NM_001303235 NM_001303236 NM_001303237 NM_002201	n/a
RefSeq (protein)	NP_001290162 NP_001290163 NP_001290164 NP_001290165 NP_001290166 NP_002192	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ISG20 yw ISG20 a elwir hefyd yn Interferon-stimulated gene 20 kDa protein ac Interferon stimulated exonuclease gene 20 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q26.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ISG20.

• CD25
• HEM45

Llyfryddiaeth

• "Influenza A Virus-induced expression of ISG20 inhibits viral replication by interacting with nucleoprotein. ". Virus Genes. 2016. PMID 27342813.
• "Cloning, eukaryotic expression of human ISG20 and preliminary study on the effect of its anti-HBV. ". J Huazhong Univ Sci Technolog Med Sci. 2008. PMID 18278447.
• "Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease. ". FEBS Lett. 2004. PMID 15527770.
• "Assignment of ISG20 encoding a new interferon-induced PML nuclear body-associated protein, to chromosome 15q26 by in situ hybridization. ". Cytogenet Cell Genet. 1997. PMID 9605874.
• "Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus.". J Steroid Biochem Mol Biol. 1998. PMID 9569007.