ISG15

ISG15
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Z2M, 2HJ8, 3PHX, 3PSE, 3R66, 3RT3, 3SDL
Dynodwyr
Cyfenwau	ISG15, G1P2, IFI15, IP17, UCRP, hUCRP, IMD38, ISG15 ubiquitin-like modifier, ISG15 ubiquitin like modifier
Dynodwyr allanol	OMIM: 147571 HomoloGene: 48326 GeneCards: ISG15
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein tag • integrin binding Cydrannau o'r gell • cytoplasm • cytosol • nucleoplasm • extracellular region Prosesau biolegol • immune system process • regulation of interferon-gamma production • negative regulation of protein ubiquitination • negative regulation of viral genome replication • defense response to virus • type I interferon signaling pathway • response to type I interferon • translesion synthesis • negative regulation of type I interferon production • GO:0022415 viral process • innate immune response • modification-dependent protein catabolic process • positive regulation of bone mineralization • ISG15-protein conjugation • defense response to bacterium • positive regulation of erythrocyte differentiation • response to bacterium • integrin-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9636	n/a
Ensembl	ENSG00000187608	n/a
UniProt	P05161	n/a
RefSeq (mRNA)	NM_005101	n/a
RefSeq (protein)	NP_005092	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ISG15 yw ISG15 a elwir hefyd yn ISG15 ubiquitin-like modifier (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ISG15.

• G1P2
• IP17
• UCRP
• IFI15
• IMD38
• hUCRP

Llyfryddiaeth

• "ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma. ". Oncotarget. 2016. PMID 26919245.
• "Interferon-Stimulated Gene 15, a Type I Interferon-Dependent Transcript, Is Involved in a Negative Feedback Loop in Innate Immune Reactions in Human Mesangial Cells. ". Nephron. 2016. PMID 26844778.
• "ISG15 Modulates Type I Interferon Signaling and the Antiviral Response during Hepatitis E Virus Replication. ". J Virol. 2017. PMID 28724761.
• "Unconjugated interferon-stimulated gene 15 specifically interacts with the hepatitis C virus NS5A protein via domain I. ". Microbiol Immunol. 2017. PMID 28543875.
• "Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing.". J Virol. 2017. PMID 28202760.