IL1A

Interleukin 1-alpha
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2ILA, 2KKI, 2L5X
Dynodwyr
Cyfenwau	IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1, interleukin 1 alpha, IL-1 alpha, IL-1α
Dynodwyr allanol	OMIM: 147760 HomoloGene: 480 GeneCards: IL1A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • GO:0001948, GO:0016582 protein binding • copper ion binding • interleukin-1 receptor binding Cydrannau o'r gell • cytosol • extracellular region • cytoplasm • extracellular space Prosesau biolegol • cellular response to heat • response to copper ion • positive regulation of angiogenesis • GO:1901313 positive regulation of gene expression • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • connective tissue replacement involved in inflammatory response wound healing • positive regulation of protein secretion • extrinsic apoptotic signaling pathway in absence of ligand • ectopic germ cell programmed cell death • positive regulation of vascular endothelial growth factor production • cell population proliferation • inflammatory response • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of mitotic nuclear division • positive regulation of cell division • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • GO:0097285 apoptotic process • positive regulation of interleukin-6 production • positive regulation of neutrophil extravasation • fever generation • positive regulation of monocyte chemotactic protein-1 production • regulation of signaling receptor activity • cytokine-mediated signaling pathway • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3552	n/a
Ensembl	ENSG00000115008	n/a
UniProt	P01583	n/a
RefSeq (mRNA)	NM_000575 NM_001371554	n/a
RefSeq (protein)	NP_000566 NP_001358483	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL1A yw IL1A a elwir hefyd yn Interleukin 1 alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q14.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL1A.

• IL1
• IL-1A
• IL1F1
• IL1-ALPHA

Llyfryddiaeth

• "Association of Interleukin-1 gene clusters polymorphisms with primary open-angle glaucoma: a meta-analysis. ". BMC Ophthalmol. 2017. PMID 29179746.
• "Functional polymorphism rs3783553 in the 3'-untranslated region of IL-1A increased the risk of ischemic stroke: A case-control study. ". Medicine (Baltimore). 2017. PMID 29145255.
• "Association of interleukin-1A insertion/deletion gene polymorphism and possible high risk factors with non-alcoholic fatty liver disease in Egyptian patients. ". Arch Physiol Biochem. 2017. PMID 28627263.
• "IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease. ". Pharmacogenomics. 2016. PMID 27883292.
• "Association of IL-1α gene polymorphism with susceptibility to type 1 diabetes in Chinese children.". Genet Mol Res. 2016. PMID 27706611.