HMGB1 Dynodwyr Cyfenwau HMGB1 Dynodwyr allanol OMIM: 163905 HomoloGene: 110676 GeneCards: HMGB1 Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • bubble DNA binding • DNA polymerase binding • C-X-C chemokine binding • transcription factor binding • phosphatidylserine binding • lipopolysaccharide binding • lyase activity • single-stranded DNA binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • DNA binding, bending • supercoiled DNA binding • DNA binding • four-way junction DNA binding • RAGE receptor binding • chemoattractant activity • RNA binding • double-stranded DNA binding • double-stranded RNA binding • single-stranded RNA binding • cytokine activity • calcium-dependent protein kinase regulator activity • protein kinase activator activity • GO:0001105 transcription coactivator activity • integrin binding Cydrannau o'r gell • cytoplasm • endosome • bilen • transcription repressor complex • extracellular region • cnewyllyn cell • cell surface • Cellbilen • nucleoplasm • Cromosom • condensed chromosome • endoplasmic reticulum-Golgi intermediate compartment • secretory granule lumen • ficolin-1-rich granule lumen • extracellular space • early endosome • neuron projection • alphav-beta3 integrin-HMGB1 complex Prosesau biolegol • T-helper 1 cell activation • apoptotic DNA fragmentation • adaptive immune response • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • positive regulation of DNA ligation • positive regulation of JNK cascade • cellular response to DNA damage stimulus • apoptotic cell clearance • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of toll-like receptor 9 signaling pathway • negative regulation of RNA polymerase II transcription preinitiation complex assembly • positive regulation of dendritic cell differentiation • positive regulation of DNA binding • neuron projection development • negative regulation of blood vessel endothelial cell migration • positive regulation of interleukin-12 production • positive regulation of monocyte chemotaxis • activation of innate immune response • DNA ligation involved in DNA repair • innate immune response • inflammatory response • GO:0100026 DNA repair • positive regulation of MAPK cascade • positive regulation of activated T cell proliferation • DNA geometric change • DNA recombination • inflammatory response to antigenic stimulus • positive regulation of interleukin-10 production • immune system process • GO:1901227 negative regulation of transcription by RNA polymerase II • regulation of restriction endodeoxyribonuclease activity • chemotaxis • positive regulation of mismatch repair • negative regulation of CD4-positive, alpha-beta T cell differentiation • positive regulation of cytosolic calcium ion concentration • T-helper 1 cell differentiation • dendritic cell chemotaxis • autophagy • neutrophil clearance • V(D)J recombination • positive regulation of apoptotic process • DNA topological change • positive chemotaxis • toll-like receptor signaling pathway • neutrophil degranulation • eye development • myeloid dendritic cell activation • positive regulation of protein phosphorylation • endothelial cell proliferation • plasmacytoid dendritic cell activation • macrophage activation involved in immune response • regulation of tolerance induction • regulation of T cell mediated immune response to tumor cell • base-excision repair • regulation of autophagy • lung development • activation of protein kinase activity • positive regulation of interferon-alpha production • positive regulation of interferon-beta production • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • positive regulation of toll-like receptor 2 signaling pathway • positive regulation of toll-like receptor 4 signaling pathway • endothelial cell chemotaxis • positive regulation of innate immune response • positive regulation of myeloid cell differentiation • positive regulation of glycogen catabolic process • regulation of protein kinase activity • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • response to glucocorticoid • positive regulation of ERK1 and ERK2 cascade • positive regulation of wound healing • positive regulation of NIK/NF-kappaB signaling • positive regulation of sprouting angiogenesis • negative regulation of apoptotic cell clearance • regulation of nucleotide-excision repair • regulation of signaling receptor activity • chromatin remodeling • positive regulation of autophagy • GO:0007571 developmental process • positive regulation of blood vessel endothelial cell migration • cell chemotaxis • cellular response to lipopolysaccharide • positive regulation of vascular endothelial cell proliferation • negative regulation of interferon-gamma production • positive regulation of monocyte chemotactic protein-1 production • cellular response to interleukin-7 Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn HMGB1 yw HMGB1 a elwir hefyd yn High-mobility group box 1, isoform CRA_a (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q12.3.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HMGB1.
"HMGB1 Expression Level in Circulating Platelets is not Significantly Associated with Outcomes in Symptomatic Coronary Artery Disease. ". Cell Physiol Biochem . 2017. PMID 29041001 . "Human Endothelial Progenitor Cell-Derived Exosomes Increase Proliferation and Angiogenesis in Cardiac Fibroblasts by Promoting the Mesenchymal-Endothelial Transition and Reducing High Mobility Group Box 1 Protein B1 Expression. ". DNA Cell Biol . 2017. PMID 28920705 . "High-mobility group box 1 released by autophagic cancer-associated fibroblasts maintains the stemness of luminal breast cancer cells. ". J Pathol . 2017. PMID 28802057 . "Roles of High Mobility Group Box 1 in Cardiovascular Calcification. ". Cell Physiol Biochem . 2017. PMID 28571029 . "Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy. ". J Clin Invest . 2017. PMID 28504645 . 
