GABARAP

GABARAP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GNU, 1KLV, 1KM7, 1KOT, 3D32, 3DOW, 3WIM, 4XC2
Dynodwyr
Cyfenwau	GABARAP, ATG8A, GABARAP-a, MM46, GABA type A receptor-associated protein
Dynodwyr allanol	OMIM: 605125 HomoloGene: 134119 GeneCards: GABARAP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • microtubule binding • GO:0001948, GO:0016582 protein binding • beta-tubulin binding • ubiquitin protein ligase binding • GABA receptor binding Cydrannau o'r gell • cytoplasm • cell body • Golgi apparatus • bilen • Golgi membrane • Cellbilen • microtubule associated complex • smooth endoplasmic reticulum • autophagosome • autophagosome membrane • actin cytoskeleton • perinuclear region of cytoplasm • GO:0035085 axoneme • lysosome • sperm midpiece • Cytosgerbwd • microtubule • GO:0016023 cytoplasmic vesicle • endomembrane system • cytosol Prosesau biolegol • chemical synaptic transmission • protein targeting • autophagy • protein transport • macroautophagy • microtubule cytoskeleton organization • extrinsic apoptotic signaling pathway via death domain receptors • GO:0097285 apoptotic process • GO:0000046 autophagosome maturation • autophagosome assembly • autophagy of mitochondrion • cellular response to nitrogen starvation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11337	n/a
Ensembl	ENSG00000170296	n/a
UniProt	O95166	n/a
RefSeq (mRNA)	NM_007278	n/a
RefSeq (protein)	NP_009209	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GABARAP yw GABARAP a elwir hefyd yn GABA type A receptor-associated protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GABARAP.

• MM46
• ATG8A
• GABARAP-a

Llyfryddiaeth

• "Altered GABA(A) receptor expression during epileptogenesis. ". Neurosci Lett. 2011. PMID 21376781.
• "Assessment of GABARAP self-association by its diffusion properties. ". J Biomol NMR. 2010. PMID 20665069.
• "GABA A receptor Ï€ subunit promotes apoptosis of HTR-8/SVneo trophoblastic cells: Implications in preeclampsia. ". Int J Mol Med. 2016. PMID 27221053.
• "Human GABARAP can restore autophagosome biogenesis in a C. elegans lgg-1 mutant. ". Autophagy. 2014. PMID 25126728.
• "GABARBP down-regulates HIF-1α expression through the VEGFR-2 and PI3K/mTOR/4E-BP1 pathways.". Cell Signal. 2014. PMID 24686084.