GAB2

GAB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2VWF, 2W0Z, 5EXA, 5EWZ
Dynodwyr
Cyfenwau	GAB2, entrez:9846, GRB2 associated binding protein 2
Dynodwyr allanol	OMIM: 606203 HomoloGene: 69067 GeneCards: GAB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatidylinositol-3,4,5-trisphosphate binding • transmembrane receptor protein tyrosine kinase adaptor activity • phosphatidylinositol-3,4-bisphosphate binding • GO:0001948, GO:0016582 protein binding • 1-phosphatidylinositol-3-kinase activity Cydrannau o'r gell • cytosol • Cellbilen • bilen • cytoplasm Prosesau biolegol • positive regulation of mast cell degranulation • osteoclast differentiation • phosphatidylinositol-mediated signaling • positive regulation of cell population proliferation • Fc-epsilon receptor signaling pathway • transmembrane receptor protein tyrosine kinase signaling pathway • axon guidance • cytokine-mediated signaling pathway • phosphatidylinositol-3-phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9846	n/a
Ensembl	ENSG00000033327	n/a
UniProt	Q9UQC2	n/a
RefSeq (mRNA)	NM_012296 NM_080491	n/a
RefSeq (protein)	NP_036428 NP_536739	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GAB2 yw GAB2 a elwir hefyd yn GRB2 associated binding protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q14.1.

Llyfryddiaeth

• "Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during CoxsackievirusInfection. ". Front Cell Infect Microbiol. 2017. PMID 28361043.
• "GAB2 rs2373115 variant contributes to Alzheimer's disease risk specifically in European population. ". J Neurol Sci. 2017. PMID 28320126.
• "Expression Pattern and Clinical Significance of Gab2 Protein in Hepatocellular Carcinoma. ". Clin Lab. 2016. PMID 27544933.
• "GAB2 promotes cell proliferation by activating the ERK signaling pathway in hepatocellular carcinoma. ". Tumour Biol. 2016. PMID 27026230.
• "Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer.". J Exp Clin Cancer Res. 2016. PMID 26754532.