EWSR1

EWSR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CPE
Dynodwyr
Cyfenwau	EWSR1, EWS, bK984G1.4, EWS-FLI1, Ewing sarcoma breakpoint region 1, EWS RNA binding protein 1
Dynodwyr allanol	OMIM: 133450 HomoloGene: 136069 GeneCards: EWSR1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • GO:0001948, GO:0016582 protein binding • calmodulin binding • identical protein binding • nucleic acid binding • RNA binding Cydrannau o'r gell • cytoplasm • Cellbilen • nucleolus • bilen • cnewyllyn cell Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2130	n/a
Ensembl	ENSG00000182944	n/a
UniProt	Q01844	n/a
RefSeq (mRNA)	NM_001163285 NM_001163286 NM_001163287 NM_005243 NM_013986	n/a
RefSeq (protein)	NP_001156757 NP_001156758 NP_001156759 NP_005234 NP_053733	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EWSR1 yw EWSR1 a elwir hefyd yn EWS RNA binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q12.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EWSR1.

• EWS
• EWS-FLI1
• bK984G1.4

Llyfryddiaeth

• "Identification of two types of GGAA-microsatellites and their roles in EWS/FLI binding and gene regulation in Ewing sarcoma. ". PLoS One. 2017. PMID 29091716.
• "EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma. ". Oncogene. 2017. PMID 28671673.
• "EWSR1 rearrangement is a frequent event in papillary thyroid carcinoma and in carcinoma of the thyroid with Ewing family tumor elements (CEFTE). ". Virchows Arch. 2017. PMID 28236059.
• "Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus. ". Cancer Res. 2016. PMID 27697767.
• "Clinicopathologic and radiologic features of extraskeletal myxoid chondrosarcoma: a retrospective study of 40 Chinese cases with literature review.". Ann Diagn Pathol. 2016. PMID 27402218.