ENO1

ENO1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2PSN, 3B97
Dynodwyr
Cyfenwau	ENO1, ENO1L1, MPB1, NNE, PPH, HEL-S-17, enolase 1
Dynodwyr allanol	OMIM: 172430 HomoloGene: 134343 GeneCards: ENO1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • metal ion binding • GO:0001948, GO:0016582 protein binding • lyase activity • GTPase binding • magnesium ion binding • RNA binding • cadherin binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • phosphopyruvate hydratase activity • protein homodimerization activity • RNA polymerase II transcription regulatory region sequence-specific DNA binding Cydrannau o'r gell • cytoplasm • M band • bilen • extracellular exosome • cnewyllyn cell • extracellular space • phosphopyruvate hydratase complex • cytosol • Cellbilen • cell surface • cell cortex region Prosesau biolegol • gluconeogenesis • GO:0009373 regulation of transcription, DNA-templated • glycolytic process • response to virus • transcription, DNA-templated • negative regulation of cell growth • GO:0045996 negative regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of plasminogen activation • positive regulation of muscle contraction • canonical glycolysis • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway • positive regulation of ATP biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2023	n/a
Ensembl	ENSG00000074800	n/a
UniProt	P06733	n/a
RefSeq (mRNA)	NM_001201483 NM_001428 NM_001353346	n/a
RefSeq (protein)	NP_001188412 NP_001419 NP_001340275	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ENO1 yw ENO1 a elwir hefyd yn Enolase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ENO1.

• NNE
• PPH
• MPB1
• ENO1L1
• HEL-S-17

Llyfryddiaeth

• "Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma. ". Int J Oncol. 2016. PMID 27210467.
• "Soluble alpha-enolase activates monocytes by CD14-dependent TLR4 signalling pathway and exhibits a dual function. ". Sci Rep. 2016. PMID 27025255.
• "Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest. ". Oncotarget. 2016. PMID 26734996.
• "CD4(+) T cell surface alpha enolase is lower in older adults. ". Mech Ageing Dev. 2015. PMID 26432922.
• "Cellular stress induces cap-independent alpha-enolase/MBP-1 translation.". FEBS Lett. 2015. PMID 26144282.