EIF5A

EIF5A
Strwythurau PDB Human UniProt search: I3L397 PDBe I3L397 RCSB Rhestr o ddynodwyr PDB 3CPF, 5DLQ
Dynodwyr
Cyfenwau	EIF5A, EIF-5A, EIF5A1, eIF5AI, eukaryotic translation initiation factor 5A, eIF-4D, FABAS
Dynodwyr allanol	OMIM: 600187 HomoloGene: 133803 GeneCards: EIF5A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein N-terminus binding • ribosome binding • translation elongation factor activity • GO:0001948, GO:0016582 protein binding • RNA binding • U6 snRNA binding Cydrannau o'r gell • cytoplasm • cytosol • endoplasmic reticulum membrane • bilen • nuclear pore • lamellae anulatae • Reticwlwm endoplasmig • extracellular exosome • cnewyllyn cell • dendrite • neuronal cell body Prosesau biolegol • mRNA transport • protein biosynthesis • positive regulation of translational elongation • translational elongation • mRNA export from nucleus • peptidyl-lysine modification to peptidyl-hypusine • nucleocytoplasmic transport • protein export from nucleus • positive regulation of cell population proliferation • protein transport • translational frameshifting • positive regulation of translational termination • GO:0097285 apoptotic process • positive regulation of cytosolic calcium ion concentration • GO:0010260 heneiddio • positive regulation of cardiac muscle cell apoptotic process • positive regulation of apoptotic process • negative regulation of apoptotic process • positive regulation of muscle cell differentiation • cellular response to thyroid hormone stimulus • positive regulation of reactive oxygen species metabolic process • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1984	n/a
Ensembl	ENSG00000132507 ENSG00000288145	n/a
UniProt	P63241	n/a
RefSeq (mRNA)	NM_001143760 NM_001143761 NM_001143762 NM_001970 NM_001370420 NM_001370421	n/a
RefSeq (protein)	NP_001137232 NP_001137233 NP_001137234 NP_001961 NP_001357349 NP_001357350	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF5A yw EIF5A a elwir hefyd yn Eukaryotic translation initiation factor 5A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17p13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF5A.

• EIF-5A
• EIF5A1
• eIF5AI

Llyfryddiaeth

• "Alternative Start Codon Connects eIF5A to Mitochondria. ". J Cell Physiol. 2016. PMID 27414022.
• "Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels. ". J Biol Chem. 2015. PMID 26483550.
• "Platelet proteomics in thalassemia: Factors responsible for hypercoagulation. ". Proteomics Clin Appl. 2016. PMID 26403856.
• "Expression of eukaryotic translation initiation factor 5A-2 (eIF5A-2) associated with poor survival in gastric cancer. ". Tumour Biol. 2016. PMID 26282002.
• "The translation factor eIF5A and human cancer.". Biochim Biophys Acta. 2015. PMID 25979826.