CBX8

CBX8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3I91, 5EQ0, 2N4Q
Dynodwyr
Cyfenwau	CBX8, PC3, RC1, chromobox 8
Dynodwyr allanol	OMIM: 617354 HomoloGene: 32199 GeneCards: CBX8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • methylated histone binding • GO:0001948, GO:0016582 protein binding • single-stranded RNA binding • ubiquitin-protein transferase activator activity Cydrannau o'r gell • ubiquitin ligase complex • nucleoplasm • GO:0035328 heterochromatin • PRC1 complex • PcG protein complex • cnewyllyn cell Prosesau biolegol • positive regulation of collagen biosynthetic process • GO:0009373 regulation of transcription, DNA-templated • GO:1900404 positive regulation of DNA repair • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • positive regulation of cell population proliferation • GO:0048552 regulation of catalytic activity • histone ubiquitination • cellular response to hydrogen peroxide • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	57332	n/a
Ensembl	ENSG00000141570	n/a
UniProt	Q9HC52	n/a
RefSeq (mRNA)	NM_020649	n/a
RefSeq (protein)	NP_065700	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CBX8 yw CBX8 a elwir hefyd yn Chromobox 8 a Chromobox protein homolog 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CBX8.

• PC3
• RC1

Llyfryddiaeth

• "Evaluating of suppressor of zeste 12 and chromobox homolog 8 genes expression showed two possible origins for gastric cancer development. ". Indian J Cancer. 2015. PMID 26837964.
• "Insulin-Like Growth Factor-1 Modulates Polycomb Cbx8 Expression and Inhibits Colon Cancer Cell Apoptosis. ". Cell Biochem Biophys. 2015. PMID 25398592.
• "Paradoxical role of CBX8 in proliferation and metastasis of colorectal cancer. ". Oncotarget. 2014. PMID 25360999.
• "Chromobox homolog 8 is a predictor of muscle invasive bladder cancer and promotes cell proliferation by repressing the p53 pathway. ". Cancer Sci. 2017. PMID 28837252.
• "A Novel Role of Chromodomain Protein CBX8 in DNA Damage Response.". J Biol Chem. 2016. PMID 27555324.