CASP2

CASP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1PYO, 2P2C, 3R5J, 3R6G, 3R6L, 3R7B, 3R7N, 3R7S, 3RJM
Dynodwyr
Cyfenwau	CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57, caspase 2
Dynodwyr allanol	OMIM: 600639 HomoloGene: 7254 GeneCards: CASP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cysteine-type peptidase activity • protein domain specific binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • enzyme binding • hydrolase activity • identical protein binding • cysteine-type endopeptidase activity involved in apoptotic process • cysteine-type endopeptidase activity • cysteine-type endopeptidase activity involved in execution phase of apoptosis Cydrannau o'r gell • cytoplasm • cytosol • bilen • mitocondria • cnewyllyn cell Prosesau biolegol • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • execution phase of apoptosis • protein processing • GO:0010260 heneiddio • positive regulation of apoptotic signaling pathway • luteolysis • cellular response to mechanical stimulus • positive regulation of neuron apoptotic process • brain development • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of apoptotic process • ectopic germ cell programmed cell death • apoptotic signaling pathway • neural retina development • GO:0097285 apoptotic process • regulation of apoptotic process • proteolysis • negative regulation of apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	835	n/a
Ensembl	ENSG00000106144	n/a
UniProt	P42575	n/a
RefSeq (mRNA)	NM_032983 NM_001224 NM_032982 NM_032984	n/a
RefSeq (protein)	NP_001215 NP_116764 NP_116765	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CASP2 yw CASP2 a elwir hefyd yn Caspase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q34.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CASP2.

• ICH1
• NEDD2
• CASP-2
• NEDD-2
• PPP1R57

Llyfryddiaeth

• "Mechanism of caspase-2 activation upon DNA damage. ". Dokl Biochem Biophys. 2016. PMID 27193717.
• "Caspase-2 regulates oncogene-induced senescence. ". Oncotarget. 2014. PMID 25114039.
• "Importance of transcript levels of caspase-2 isoforms S and L for breast carcinoma progression. ". Future Oncol. 2013. PMID 23469978.
• "Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike. ". J Biol Chem. 2012. PMID 22825847.
• "Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice.". J Biol Chem. 2012. PMID 22396545.