CALR

CALR
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3POW, 2CLR, 3DOW, 3POS
Dynodwyr
Cyfenwau	CALR, CRT, HEL-S-99n, RO, SSA, cC1qR, calreticulin
Dynodwyr allanol	OMIM: 109091 HomoloGene: 37911 GeneCards: CALR
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • protein folding chaperone activity; • carbohydrate binding; • hormone binding; • metal ion binding; • complement component C1q complex binding; • mRNA binding; • iron ion binding; • unfolded protein binding; • zinc ion binding; • integrin binding; • DNA binding; • chaperone binding; • peptide binding; • androgen receptor binding; • ubiquitin protein ligase binding; • RNA binding; • GO:0001948, GO:0016582 protein binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • endoplasmic reticulum lumen; • bilen; • focal adhesion; • extracellular region; • perinuclear region of cytoplasm; • sarcoplasmic reticulum lumen; • cnewyllyn cell; • endocytic vesicle lumen; • cell surface; • Reticwlwm endoplasmig; • extracellular exosome; • Golgi apparatus; • intracellular membrane-bounded organelle; • GO:0005578 extracellular matrix; • intracellular anatomical structure; • integral component of lumenal side of endoplasmic reticulum membrane; • sarcoplasmic reticulum; • smooth endoplasmic reticulum; • MHC class I peptide loading complex; • acrosomal vesicle; • external side of plasma membrane; • polysome; • phagocytic vesicle membrane; • endoplasmic reticulum-Golgi intermediate compartment membrane; • extracellular space; • nuclear envelope; • GO:0009327 protein-containing complex; • endoplasmic reticulum quality control compartment; • collagen-containing extracellular matrix;
Prosesau biolegol	• negative regulation of neuron differentiation; • protein folding in endoplasmic reticulum; • receptor-mediated endocytosis; • response to organic substance; • cellular senescence; • spermatogenesis; • positive regulation of dendritic cell chemotaxis; • regulation of apoptotic process; • cellular response to organic substance; • positive regulation of phagocytosis; • negative regulation of intracellular steroid hormone receptor signaling pathway; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of retinoic acid receptor signaling pathway; • cardiac muscle cell differentiation; • regulation of meiotic nuclear division; • protein maturation by protein folding; • positive regulation of cell cycle; • protein export from nucleus; • cellular response to lithium ion; • peptide antigen assembly with MHC class I protein complex; • antigen processing and presentation of peptide antigen via MHC class I; • protein stabilization; • cellular calcium ion homeostasis; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of DNA replication; • protein folding; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0033109 cortical actin cytoskeleton organization; • chaperone-mediated protein folding; • response to estradiol; • response to testosterone; • ATF6-mediated unfolded protein response; • positive regulation of substrate adhesion-dependent cell spreading; • sequestering of calcium ion; • GO:1901313 positive regulation of gene expression; • positive regulation of cell population proliferation; • protein localization to nucleus; • glucocorticoid receptor signaling pathway; • positive regulation of NIK/NF-kappaB signaling; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • negative regulation of translation; • vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane; • positive regulation of endothelial cell migration; • negative regulation of trophoblast cell migration;
	Sources:Amigo / QuickGO
Orthologau
	811
	n/a
	ENSG00000179218
	n/a
	P27797
	n/a
	NM_004343
	n/a
	NP_004334
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CALR yw CALR a elwir hefyd yn Calreticulin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.13.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CALR.

RO
CRT
SSA
cC1qR
HEL-S-99n

Llyfryddiaeth[golygu | golygu cod]

"Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrin β1. ". Endocrinology. 2017. PMID 28938427.
"Somatic mutations of calreticulin in myeloproliferative neoplasms. ". Int J Hematol. 2017. PMID 28470469.
"Mannan-binding lectin, a serum collectin, suppresses T-cell proliferation viadirect interaction with cell surface calreticulin and inhibition of proximal T-cell receptor signaling. ". FASEB J. 2017. PMID 28209773.
"Progenitor genotyping reveals a complex clonal architecture in a subset of CALR-mutated myeloproliferative neoplasms. ". Br J Haematol. 2017. PMID 28168700.
"JAK2, MPL, and CALR mutations in Chinese Han patients with essential thrombocythemia.". Hematology. 2017. PMID 27875935.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] CALR - Cronfa NCBI

[1]

[2]