APLP1

APLP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3PMR, 3Q7G, 3Q7L, 3QMK, 4RD9, 4RDA
Dynodwyr
Cyfenwau	APLP1, APLP, amyloid beta precursor like protein 1
Dynodwyr allanol	OMIM: 104775 HomoloGene: 68447 GeneCards: APLP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • alpha-2C adrenergic receptor binding • heparin binding • alpha-2B adrenergic receptor binding • metal ion binding • GO:0001948, GO:0016582 protein binding • alpha-2A adrenergic receptor binding • identical protein binding • transition metal ion binding Cydrannau o'r gell • cytoplasm • integral component of membrane • bilen • Cellbilen • basement membrane • perinuclear region of cytoplasm Prosesau biolegol • endocytosis • nervous system development • cellular response to norepinephrine stimulus • cell adhesion • animal organ morphogenesis • GO:0097285 apoptotic process • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	333	n/a
Ensembl	ENSG00000105290	n/a
UniProt	P51693	n/a
RefSeq (mRNA)	NM_005166 NM_001024807	n/a
RefSeq (protein)	NP_001019978 NP_005157	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn APLP1 yw APLP1 a elwir hefyd yn Amyloid-like protein 1 ac Amyloid beta precursor like protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn APLP1.

• APLP

Llyfryddiaeth

• "Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes. ". Acta Crystallogr D Biol Crystallogr. 2015. PMID 25760599.
• "Turnover of amyloid precursor protein family members determines their nuclear signaling capability. ". PLoS One. 2013. PMID 23874953.
• "The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system. ". EMBO Mol Med. 2009. PMID 20049724.
• "gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. ". Brain Res. 2009. PMID 19401174.
• "Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract.". Endocr Relat Cancer. 2008. PMID 18430897.