APIP

APIP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4M6R
Dynodwyr
Cyfenwau	APIP, APIP2, CGI29, MMRP19, hCGI-29, APAF1 interacting protein
Dynodwyr allanol	OMIM: 612491 HomoloGene: 6277 GeneCards: APIP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • metal ion binding • lyase activity • identical protein binding • methylthioribulose 1-phosphate dehydratase activity • zinc ion binding Cydrannau o'r gell • cytoplasm • cytosol Prosesau biolegol • methionine biosynthetic process • negative regulation of apoptotic process • cellular amino acid biosynthetic process • regulation of ERK1 and ERK2 cascade • GO:0097285 apoptotic process • pyroptosis • protein homotetramerization • L-methionine salvage from methylthioadenosine • L-methionine salvage from S-adenosylmethionine Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51074	n/a
Ensembl	ENSG00000149089	n/a
UniProt	Q96GX9	n/a
RefSeq (mRNA)	NM_015957	n/a
RefSeq (protein)	NP_057041	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn APIP yw APIP a elwir hefyd yn APAF1 interacting protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn APIP.

• APIP2
• CGI29
• hAPIP
• CGI-29
• MMRP19

Llyfryddiaeth

• "Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma. ". Int J Oncol. 2012. PMID 22407486.
• "APIP, an ERBB3-binding partner, stimulates erbB2-3 heterodimer formation to promote tumorigenesis. ". Oncotarget. 2016. PMID 26942872.
• "Crystallization and preliminary X-ray crystallographic analysis of human Apaf-1-interacting protein. ". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID 23192037.
• "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme. ". Proc Natl Acad Sci U S A. 2014. PMID 24367089.
• "Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway.". PLoS One. 2012. PMID 23285211.