AFDN

AFDN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1T2M, 1XZ9, 2AIN, 2EXG, 5A6C
Dynodwyr
Cyfenwau	AFDN, AF6, MLL-AF6, MLLT4, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4, afadin, adherens junction formation factor, l-afadin
Dynodwyr allanol	OMIM: 159559 HomoloGene: 21202 GeneCards: AFDN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • cadherin binding • cell adhesion molecule binding • actin filament binding Cydrannau o'r gell • adherens junction • cell junction • Cellbilen • nucleoplasm • cytosol • cell-cell junction • nuclear speck • cell-cell contact zone • tight junctions Prosesau biolegol • cell-cell signaling • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • cell adhesion • establishment of endothelial intestinal barrier • GO:0072468 signal transduction • regulation of protein localization • adherens junction organization • GO:1901313 positive regulation of gene expression • positive regulation of cell-cell adhesion • negative regulation of cell migration • cell-cell adhesion mediated by cadherin • establishment of protein localization to plasma membrane • bicellular tight junction assembly • positive regulation of cell-cell adhesion mediated by cadherin Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4301	n/a
Ensembl	ENSG00000130396	n/a
UniProt	P55196	n/a
RefSeq (mRNA)	NM_001040000 NM_001040001 NM_001207008 NM_001291964 NM_005936 NM_001366319 NM_001366320 NM_001366321 NM_001386888	n/a
RefSeq (protein)	NP_001035089 NP_001193937 NP_001278893 NP_001353248 NP_001353249 NP_001353250	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AFDN yw AFDN a elwir hefyd yn Afadin, adherens junction formation factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q27.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AFDN.

• AF6
• MLLT4
• MLL-AF6
• l-afadin

Llyfryddiaeth

• "Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancer. ". BMC Cancer. 2015. PMID 25879875.
• "Interesting structural and dynamical behaviors exhibited by the AF-6 PDZ domain upon Bcr peptide binding. ". Biochemistry. 2007. PMID 18052198.
• "Role of AF6 protein in cell-to-cell spread of Herpes simplex virus 1. ". FEBS Lett. 2007. PMID 17967423.
• "Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton. ". J Cell Sci. 2006. PMID 16882694.
• "Nectin and afadin: novel organizers of intercellular junctions.". J Cell Sci. 2003. PMID 12456712.