ZIC3

ZIC3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EJ4, 2RPC
Dynodwyr
Cyfenwau	ZIC3, HTX, HTX1, VACTERLX, ZNF203, Zic family member 3
Dynodwyr allanol	OMIM: 300265 HomoloGene: 55742 GeneCards: ZIC3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • DNA binding • nucleic acid binding • sequence-specific DNA binding • metal ion binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cnewyllyn cell • nucleoplasm Prosesau biolegol • determination of left/right symmetry • somatic stem cell population maintenance • determination of pancreatic left/right asymmetry • nervous system development • determination of digestive tract left/right asymmetry • multicellular organism development • heart looping • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • anterior/posterior pattern specification • determination of liver left/right asymmetry • pattern specification process • transcription, DNA-templated • lung development • determination of left/right asymmetry in nervous system • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • central nervous system development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7547	n/a
Ensembl	ENSG00000156925	n/a
UniProt	O60481	n/a
RefSeq (mRNA)	NM_003413 NM_001330661	n/a
RefSeq (protein)	NP_001317590 NP_003404	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ZIC3 yw ZIC3 a elwir hefyd yn Zic family member 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq26.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ZIC3.

• HTX
• HTX1
• ZNF203
• VACTERLX

Llyfryddiaeth

• "The phenotypic spectrum of ZIC3 mutations includes isolated d-transposition of the great arteries and double outlet right ventricle. ". Am J Med Genet A. 2013. PMID 23427188.
• "Situs inversus totalis and a novel ZIC3 mutation in a family with X-linked heterotaxy. ". Congenit Heart Dis. 2013. PMID 22171628.
• "Rare novel variants in the ZIC3 gene cause X-linked heterotaxy. ". Eur J Hum Genet. 2016. PMID 27406248.
• "Genetic and functional analyses of ZIC3 variants in congenital heart disease. ". Hum Mutat. 2014. PMID 24123890.
• "Sumoylation regulates nuclear localization and function of zinc finger transcription factor ZIC3.". Biochim Biophys Acta. 2013. PMID 23872418.