ZFHX3

ZFHX3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DA1, 2DA2, 2DA3
Dynodwyr
Cyfenwau	ZFHX3, ATBF1, ATBT, ZNF927, zinc finger homeobox 3
Dynodwyr allanol	OMIM: 104155 HomoloGene: 21366 GeneCards: ZFHX3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • metal ion binding • core promoter sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • enzyme binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • nuclear body • transcription regulator complex • cnewyllyn cell • nucleoplasm Prosesau biolegol • negative regulation of myoblast differentiation • GO:0009373 regulation of transcription, DNA-templated • regulation of locomotor rhythm • muscle organ development • transcription by RNA polymerase II • circadian regulation of gene expression • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of myoblast differentiation • GO:0045996 negative regulation of transcription, DNA-templated • response to transforming growth factor beta • GO:1901227 negative regulation of transcription by RNA polymerase II • brain development • regulation of neuron differentiation • positive regulation of cell adhesion • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	463	n/a
Ensembl	ENSG00000140836	n/a
UniProt	Q15911	n/a
RefSeq (mRNA)	NM_001164766 NM_006885	n/a
RefSeq (protein)	NP_001158238 NP_008816	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ZFHX3 yw ZFHX3 a elwir hefyd yn Zinc finger homeobox 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16q22.2-q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ZFHX3.

• ATBT
• ATBF1
• ZNF927

Llyfryddiaeth

• "Cellular localization of ATBF1 protein and its functional implication in breast epithelial cells. ". Biochem Biophys Res Commun. 2017. PMID 28624455.
• "Association of ZFHX3 gene variation with atrial fibrillation, cerebral infarction, and lung thromboembolism: An autopsy study. ". J Cardiol. 2017. PMID 28007413.
• "A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression. ". BMC Cancer. 2016. PMID 27756245.
• "Zinc Finger Homeodomain Factor Zfhx3 Is Essential for Mammary Lactogenic Differentiation by Maintaining Prolactin Signaling Activity. ". J Biol Chem. 2016. PMID 27129249.
• "Rs7193343 polymorphism in zinc finger homeobox 3 (ZFHX3) gene and atrial fibrillation: an updated meta-analysis of 10 case-control comparisons.". BMC Cardiovasc Disord. 2015. PMID 26112950.