ZBTB16

ZBTB16
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BUO, 1CS3
Dynodwyr
Cyfenwau	ZBTB16, PLZF, ZNF145, zinc finger and BTB domain containing 16
Dynodwyr allanol	OMIM: 176797 HomoloGene: 21214 GeneCards: ZBTB16
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • metal ion binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • identical protein binding • nucleic acid binding • double-stranded DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • protein C-terminus binding • protein domain specific binding • sequence-specific DNA binding Cydrannau o'r gell • PML body • nuclear speck • nuclear body • Cellbilen • transcription repressor complex • cnewyllyn cell • cytosol • GO:0009327 protein-containing complex • nucleoplasm Prosesau biolegol • embryonic hindlimb morphogenesis • forelimb morphogenesis • skeletal system development • myeloid cell differentiation • GO:0009373 regulation of transcription, DNA-templated • embryonic pattern specification • embryonic digit morphogenesis • positive regulation of ossification • GO:1901227 negative regulation of transcription by RNA polymerase II • hindlimb morphogenesis • transcription, DNA-templated • mesonephros development • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • central nervous system development • cartilage development • male germ-line stem cell asymmetric division • positive regulation of cartilage development • protein ubiquitination • positive regulation of chondrocyte differentiation • positive regulation of apoptotic process • protein localization to nucleus • positive regulation of NK T cell differentiation • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of fat cell differentiation • negative regulation of myeloid cell differentiation • anterior/posterior pattern specification • negative regulation of cell population proliferation • GO:0097285 apoptotic process • post-translational protein modification • hemopoiesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7704	n/a
Ensembl	ENSG00000109906	n/a
UniProt	Q05516	n/a
RefSeq (mRNA)	NM_001018011 NM_006006 NM_001354750 NM_001354751 NM_001354752	n/a
RefSeq (protein)	NP_001018011 NP_005997 NP_001341679 NP_001341680 NP_001341681	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ZBTB16 yw ZBTB16 a elwir hefyd yn Zinc finger and BTB domain containing 16 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q23.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ZBTB16.

• PLZF
• ZNF145

Llyfryddiaeth

• "PLZF, a tumor suppressor genetically lost in metastatic castration-resistant prostate cancer, is a mediator of resistance to androgen deprivation therapy. ". Cancer Res. 2015. PMID 25808865.
• "Loss of PLZF expression in prostate cancer by immunohistochemistry correlates with tumor aggressiveness and metastasis. ". PLoS One. 2015. PMID 25807461.
• "The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization. ". PLoS Genet. 2016. PMID 27035670.
• "Concise Review: Balancing Stem Cell Self-Renewal and Differentiation with PLZF. ". Stem Cells. 2016. PMID 26676652.
• "Down-regulation of cytoplasmic PLZF correlates with high tumor grade and tumor aggression in non-small cell lung carcinoma.". Hum Pathol. 2015. PMID 26297253.