ZAP70

ZAP70
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4XZ0, 1FBV, 1M61, 1U59, 2CBL, 2OQ1, 2OZO, 2Y1N, 3ZNI, 4A4B, 4A4C, 4K2R, 4XZ1
Dynodwyr
Cyfenwau	ZAP70, SRK, STCD, STD, TZK, ZAP-70, zeta chain of T cell receptor associated protein kinase 70kDa, zeta chain of T cell receptor associated protein kinase 70, zeta chain of T-cell receptor associated protein kinase 70, IMD48, ADMIO2
Dynodwyr allanol	OMIM: 176947 HomoloGene: 839 GeneCards: ZAP70
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • protein tyrosine kinase activity • signaling receptor binding • ATP binding • phosphotyrosine residue binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • cell-cell junction • extrinsic component of cytoplasmic side of plasma membrane • Cellbilen • T cell receptor complex • immunological synapse • membrane raft Prosesau biolegol • positive regulation of T cell differentiation • T cell migration • positive regulation of calcium-mediated signaling • GO:0007243 intracellular signal transduction • adaptive immune response • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • immune system process • T cell aggregation • beta selection • negative thymic T cell selection • protein phosphorylation • B cell activation • T cell differentiation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive thymic T cell selection • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • peptidyl-tyrosine phosphorylation • innate immune response • T cell receptor signaling pathway • thymic T cell selection • positive regulation of alpha-beta T cell differentiation • T cell activation • regulation of cell population proliferation • positive regulation of alpha-beta T cell proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7535	n/a
Ensembl	ENSG00000115085	n/a
UniProt	P43403	n/a
RefSeq (mRNA)	NM_001079 NM_207519 NM_001378594	n/a
RefSeq (protein)	NP_001070 NP_997402 NP_001365523	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ZAP70 yw ZAP70 a elwir hefyd yn Zeta chain of T-cell receptor associated protein kinase 70 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ZAP70.

• SRK
• STD
• TZK
• STCD
• IMD48
• ADMIO2
• ZAP-70

Llyfryddiaeth

• "Novel compound heterozygous mutations in ZAP70 in a Chinese patient with leaky severe combined immunodeficiency disorder. ". Immunogenetics. 2017. PMID 28124082.
• "An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. ". Elife. 2016. PMID 27700984.
• "The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system. ". Haematologica. 2017. PMID 27686375.
• "Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor. ". Ann Biomed Eng. 2016. PMID 27384937.
• "SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins.". Mol Cell. 2016. PMID 27052731.