YY1

YY1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UBD, 1ZNM, 4C5I
Dynodwyr
Cyfenwau	YY1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 transcription factor, GADEVS
Dynodwyr allanol	OMIM: 600013 HomoloGene: 2556 GeneCards: YY1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001106 transcription corepressor activity • GO:0001105 transcription coactivator activity • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • four-way junction DNA binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • RNA binding • nucleic acid binding • SMAD binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • histone deacetylase binding Cydrannau o'r gell • Ino80 complex • nuclear matrix • cnewyllyn cell • nucleoplasm • transcription regulator complex • cytoplasm • PcG protein complex Prosesau biolegol • cell differentiation • DNA recombination • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • cellular response to UV • negative regulation of gene expression • transcription, DNA-templated • cellular response to DNA damage stimulus • double-strand break repair via homologous recombination • spermatogenesis • GO:0100026 DNA repair • protein deubiquitination • negative regulation of interferon-beta production • GO:1901227 negative regulation of transcription by RNA polymerase II • RNA localization • anterior/posterior pattern specification • response to UV-C • GO:1901313 positive regulation of gene expression • response to prostaglandin F • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • camera-type eye morphogenesis • GO:0051312, GO:0007083 chromosome organization • cellular response to interleukin-1 • negative regulation of pri-miRNA transcription by RNA polymerase II • negative regulation of cell growth involved in cardiac muscle cell development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7528	n/a
Ensembl	ENSG00000100811	n/a
UniProt	P25490	n/a
RefSeq (mRNA)	NM_003403	n/a
RefSeq (protein)	NP_003394	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn YY1 yw YY1 a elwir hefyd yn YY1 transcription factor a Transcriptional repressor protein YY1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn YY1.

• DELTA
• NF-E1
• UCRBP
• GADEVS
• INO80S
• YIN-YANG-1

Llyfryddiaeth

• "Significance of the pathogenic mutation T372R in the Yin Yang 1 protein interaction with DNA--thermodynamic studies. ". FEBS Lett. 2016. PMID 26910132.
• "Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma. ". J Pathol. 2016. PMID 26800240.
• "YY1 Is a Structural Regulator of Enhancer-Promoter Loops. ". Cell. 2017. PMID 29224777.
• "YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction. ". Am J Hum Genet. 2017. PMID 28575647.
• "The zinc fingers of YY1 bind single-stranded RNA with low sequence specificity.". Nucleic Acids Res. 2016. PMID 27369384.