XRCC5

XRCC5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JEQ, 1JEY, 1Q2Z, 1RW2, 3RZ9
Dynodwyr
Cyfenwau	XRCC5, KARP-1, KARP1, KU80, KUB2, Ku86, NFIV, Ku80, X-ray repair complementing defective repair in Chinese hamster cells 5, X-ray repair cross complementing 5
Dynodwyr allanol	OMIM: 194364 HomoloGene: 40681 GeneCards: XRCC5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • nucleotide binding • double-stranded telomeric DNA binding • telomeric DNA binding • GO:0008026 helicase activity • 5'-deoxyribose-5-phosphate lyase activity • GO:0004003 DNA helicase activity • hydrolase activity, acting on acid anhydrides • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • hydrolase activity • ATP binding • ubiquitin protein ligase binding • double-stranded DNA binding • damaged DNA binding • RNA binding • GO:0010577 enzyme activator activity • GO:0032403 protein-containing complex binding • DNA end binding Cydrannau o'r gell • cytoplasm • cytosol • nuclear telomere cap complex • bilen • Cellbilen • nucleoplasm • Cromosom • nucleolus • nonhomologous end joining complex • cnewyllyn cell • extracellular region • secretory granule lumen • protein-DNA complex • Ku70:Ku80 complex • GO:0009327 protein-containing complex • site of DNA damage • ribonucleoprotein complex Prosesau biolegol • DNA recombination • GO:0009373 regulation of transcription, DNA-templated • regulation of smooth muscle cell proliferation • transcription, DNA-templated • cellular response to DNA damage stimulus • positive regulation of neurogenesis • hematopoietic stem cell differentiation • double-strand break repair • negative regulation of t-circle formation • establishment of integrated proviral latency • cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of type I interferon production • cellular hyperosmotic salinity response • GO:0100026 DNA repair • DNA duplex unwinding • brain development • cellular response to fatty acid • double-strand break repair via nonhomologous end joining • neutrophil degranulation • cellular response to gamma radiation • cellular response to X-ray • telomere maintenance • regulation of telomere maintenance • positive regulation of telomere maintenance via telomerase • GO:0048554 positive regulation of catalytic activity • positive regulation of protein kinase activity • positive regulation of telomerase activity • protein localization to chromosome, telomeric region • cellular response to leukemia inhibitory factor • activation of innate immune response • immune system process • innate immune response Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7520	n/a
Ensembl	ENSG00000079246	n/a
UniProt	P13010	n/a
RefSeq (mRNA)	NM_021141	n/a
RefSeq (protein)	NP_066964	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn XRCC5 yw XRCC5 a elwir hefyd yn X-ray repair cross complementing 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q35.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn XRCC5.

• KU80
• KUB2
• Ku86
• NFIV
• KARP1
• KARP-1

Llyfryddiaeth

• "Ku80 Counters Oxidative Stress-Induced DNA Damage and Cataract Formation in the Human Lens. ". Invest Ophthalmol Vis Sci. 2015. PMID 26658510.
• "Prognostic significance of Ku80 in pT2N0M0 esophageal squamous cell carcinoma after Ivor-Lewis esophagectomy. ". Tumour Biol. 2015. PMID 25758053.
• "Cleavage of Ku80 by caspase-2 promotes non-homologous end joining-mediated DNA repair. ". DNA Repair (Amst). 2017. PMID 29065392.
• "DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). ". DNA Repair (Amst). 2017. PMID 28641126.
• "Ku80 correlates with neoadjuvant chemotherapy resistance in human lung adenocarcinoma, but reduces cisplatin/pemetrexed-induced apoptosis in A549 cells.". Respir Res. 2017. PMID 28399858.