XDH

XDH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CKJ, 2E1Q
Dynodwyr
Cyfenwau	XDH, XO, XOR, xanthine dehydrogenase, XAN1
Dynodwyr allanol	OMIM: 607633 HomoloGene: 324 GeneCards: XDH
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • protein homodimerization activity • xanthine oxidase activity • flavin adenine dinucleotide binding • oxidoreductase activity, acting on CH-OH group of donors • iron-sulfur cluster binding • metal ion binding • catalytic activity • molybdopterin cofactor binding • electron transfer activity • xanthine dehydrogenase activity • oxidoreductase activity • 2 iron, 2 sulfur cluster binding • oxidoreductase activity, acting on the aldehyde or oxo group of donors • FAD binding Cydrannau o'r gell • cytoplasm • cytosol • peroxisome • sarcoplasmic reticulum • extracellular region • extracellular space Prosesau biolegol • positive regulation of p38MAPK cascade • GO:0033128 negative regulation of protein phosphorylation • negative regulation of protein kinase B signaling • purine nucleotide catabolic process • negative regulation of endothelial cell differentiation • negative regulation of gene expression • negative regulation of endothelial cell proliferation • positive regulation of reactive oxygen species metabolic process • negative regulation of vasculogenesis • negative regulation of vascular endothelial growth factor signaling pathway • lactation • regulation of epithelial cell differentiation • xanthine catabolic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • electron transport chain Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7498	n/a
Ensembl	ENSG00000158125	n/a
UniProt	P47989	n/a
RefSeq (mRNA)	NM_000379	n/a
RefSeq (protein)	NP_000370	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn XDH yw XDH a elwir hefyd yn Xanthine dehydrogenase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2p23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn XDH.

• XO
• XOR
• XAN1

Llyfryddiaeth

• "Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells. ". PLoS One. 2017. PMID 28863172.
• "Alcohol abuse is associated with enhanced pulmonary and systemic xanthine oxidoreductase activity. ". Am J Physiol Lung Cell Mol Physiol. 2017. PMID 28839105.
• "Relationship between plasma xanthine oxidoreductase activity and left ventricular ejection fraction and hypertrophy among cardiac patients. ". PLoS One. 2017. PMID 28797123.
• "Xanthine oxidoreductase activity is correlated with insulin resistance and subclinical inflammation in young humans. ". Metabolism. 2017. PMID 28403945.
• "Conversion to purpurogallin, a key step in the mechanism of the potent xanthine oxidase inhibitory activity of pyrogallol.". Free Radic Biol Med. 2017. PMID 28223196.