WWOX

WWOX
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WMV
Dynodwyr
Cyfenwau	WWOX, D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1, EIEE28, WW domain containing oxidoreductase, DEE28
Dynodwyr allanol	OMIM: 605131 HomoloGene: 56334 GeneCards: WWOX
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001105 transcription coactivator activity • protein dimerization activity • GO:0001948, GO:0016582 protein binding • enzyme binding • oxidoreductase activity Cydrannau o'r gell • cytoplasm • cytosol • Golgi apparatus • Cellbilen • microvillus • RNA polymerase II transcription regulator complex • mitocondria • cnewyllyn cell Prosesau biolegol • cellular response to transforming growth factor beta stimulus • steroid metabolic process • extrinsic apoptotic signaling pathway • negative regulation of Wnt signaling pathway • skeletal system morphogenesis • Wnt signaling pathway • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • osteoblast differentiation • intrinsic apoptotic signaling pathway by p53 class mediator • positive regulation of extrinsic apoptotic signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0097285 apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51741	n/a
Ensembl	ENSG00000186153	n/a
UniProt	Q9NZC7	n/a
RefSeq (mRNA)	NM_001291997 NM_016373 NM_018560 NM_130788 NM_130790 NM_130791 NM_130792 NM_130844	n/a
RefSeq (protein)	NP_001278926 NP_057457 NP_570607	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn WWOX yw WWOX a elwir hefyd yn WW domain containing oxidoreductase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q23.1-q23.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn WWOX.

• FOR
• WOX1
• EIEE28
• FRA16D
• SCAR12
• HHCMA56
• PRO0128
• SDR41C1
• D16S432E

Llyfryddiaeth

• "Role of WW Domain-containing Oxidoreductase WWOX in Driving T Cell Acute Lymphoblastic Leukemia Maturation. ". J Biol Chem. 2016. PMID 27339895.
• "WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use. ". Biomed Res Int. 2016. PMID 27190995.
• "Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk. ". PLoS One. 2017. PMID 28426730.
• "Functions and Epigenetic Regulation of Wwox in Bone Metastasis from Breast Carcinoma: Comparison with Primary Tumors. ". Int J Mol Sci. 2017. PMID 28045433.
• "Ectopic WWOX Expression Inhibits Growth of 5637 Bladder Cancer Cell In Vitro and In Vivo.". Cell Biochem Biophys. 2015. PMID 27352332.