WT1

WT1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1XF7, 2JP9, 2JPA, 2PRT, 3HPJ, 3MYJ, 4R2E, 4R2P, 4R2Q, 4R2R, 4R2S, 4WUU
Dynodwyr
Cyfenwau	WT1, AEWS-GUD, NPHS4, WAGR, WIT-2, WT33, Wilms tumor 1, WT1 transcription factor, WT-1
Dynodwyr allanol	OMIM: 607102 HomoloGene: 11536 GeneCards: WT1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • C2H2 zinc finger domain binding • metal ion binding • GO:0001948, GO:0016582 protein binding • RNA binding • nucleic acid binding • double-stranded methylated DNA binding • hemi-methylated DNA-binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • nuclear speck • nucleoplasm • nucleolus • cnewyllyn cell • cytosol Prosesau biolegol • germ cell development • adrenal cortex formation • ureteric bud development • negative regulation of translation • male gonad development • male genitalia development • GO:0009373 regulation of transcription, DNA-templated • epithelial cell differentiation • glomerular basement membrane development • diaphragm development • kidney development • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • posterior mesonephric tubule development • visceral serous pericardium development • metanephric epithelium development • negative regulation of apoptotic process • glomerulus development • GO:1901227 negative regulation of transcription by RNA polymerase II • adrenal gland development • transcription, DNA-templated • positive regulation of metanephric ureteric bud development • vasculogenesis • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of heart growth • heart development • negative regulation of female gonad development • branching involved in ureteric bud morphogenesis • regulation of animal organ formation • sex-determination system • negative regulation of cell growth • RNA splicing • cardiac muscle cell fate commitment • tissue development • positive regulation of apoptotic process • camera-type eye development • metanephric S-shaped body morphogenesis • thorax and anterior abdomen determination • GO:0045996 negative regulation of transcription, DNA-templated • gonad development • metanephric mesenchyme development • cellular response to gonadotropin stimulus • positive regulation of male gonad development • cellular response to cAMP • negative regulation of cell population proliferation • mesenchymal to epithelial transition • negative regulation of metanephric glomerular mesangial cell proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • glomerular visceral epithelial cell differentiation • GO:1901313 positive regulation of gene expression • positive regulation of pri-miRNA transcription by RNA polymerase II • positive regulation of DNA methylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7490	n/a
Ensembl	ENSG00000184937	n/a
UniProt	P19544	n/a
RefSeq (mRNA)	NM_024426 NM_000378 NM_001198551 NM_001198552 NM_024424 NM_024425 NM_001367854	n/a
RefSeq (protein)	NP_000369 NP_001185480 NP_001185481 NP_077742 NP_077744 NP_001354783 NP_000369.3 NP_001185480.1 NP_001185481.1 NP_077742.2 NP_077744.3	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn WT1 yw WT1 a elwir hefyd yn WT1 protein ac Wilms tumor protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn WT1.

• GUD
• AWT1
• WAGR
• WT33
• NPHS4
• WIT-2

Llyfryddiaeth

• "Use of Wilms Tumor 1 Gene Expression as a Reliable Marker for Prognosis and Minimal Residual Disease Monitoring in Acute Myeloid Leukemia With Normal Karyotype Patients. ". Clin Lymphoma Myeloma Leuk. 2017. PMID 28163010.
• "Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. ". Oncotarget. 2017. PMID 28107196.
• "The CUG-translated WT1, not AUG-WT1, is an oncogene. ". Carcinogenesis. 2017. PMID 29040381.
• "The role of WT1 isoforms in vasculogenic mimicry and metastatic potential of human triple negative breast cancer cells. ". Biochem Biophys Res Commun. 2017. PMID 29024629.
• "WT1 mutation-associated nephropathy: a single-center experience
.". Clin Nephrol. 2017. PMID 28257282.