WASL

WASL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2FF3, 2LNH, 2VCP, 4CC2, 4CC7
Dynodwyr
Cyfenwau	WASL, N-WASP, NWASP, WASPB, WASL (gene), Wiskott-Aldrich syndrome like, WASP like actin nucleation promoting factor
Dynodwyr allanol	OMIM: 605056 HomoloGene: 136779 GeneCards: WASL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0005083 GTPase regulator activity • GO:0001948, GO:0016582 protein binding • actin binding Cydrannau o'r gell • cytoplasm • endocytic vesicle membrane • cytosol • Cellbilen • actin cytoskeleton • actin cap • extracellular exosome • Cytosgerbwd • cnewyllyn cell • lamellipodium • GO:0016023 cytoplasmic vesicle Prosesau biolegol • negative regulation of membrane tubulation • GO:0009373 regulation of transcription, DNA-templated • response to bacterium • Fc-gamma receptor signaling pathway involved in phagocytosis • vesicle organization • actin filament organization • ephrin receptor signaling pathway • regulation of nitric-oxide synthase activity • positive regulation of Arp2/3 complex-mediated actin nucleation • transcription, DNA-templated • regulation of protein localization • Cellraniad • vesicle budding from membrane • positive regulation of clathrin-dependent endocytosis • vesicle transport along actin filament • cell cycle • actin polymerization or depolymerization • spindle localization • negative regulation of lymphocyte migration • positive regulation of filopodium assembly • actin cytoskeleton organization • membrane organization • dendritic spine morphogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8976	n/a
Ensembl	ENSG00000106299	n/a
UniProt	O00401	n/a
RefSeq (mRNA)	NM_003941	n/a
RefSeq (protein)	NP_003932	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn WASL yw WASL a elwir hefyd yn Wiskott-Aldrich syndrome like (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q31.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn WASL.

• NWASP
• WASPB
• N-WASP

Llyfryddiaeth

• "N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway. ". Nat Cell Biol. 2011. PMID 21785420.
• "Interplay between N-WASP and CK2 optimizes clathrin-mediated endocytosis of EGFR. ". J Cell Sci. 2011. PMID 21610097.
• "VCA nanobodies target N-WASp to reduce invadopodium formation and functioning. ". PLoS One. 2017. PMID 28938008.
• "Role of N-WASP in Endothelial Monolayer Formation and Integrity. ". J Biol Chem. 2015. PMID 26070569.
• "Human endothelial cells internalize Candida parapsilosis via N-WASP-mediated endocytosis.". Infect Immun. 2013. PMID 23690407.