WARS

WARS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1O5T, 1R6T, 1R6U, 1ULH, 2AKE, 2AZX, 2DR2, 2QUH, 2QUI, 2QUJ, 2QUK
Dynodwyr
Cyfenwau	WARS1, Tryptophanyl-tRNA synthetase, cytoplasmic, GAMMA-2, IFI53, IFP53, tryptophanyl-tRNA synthetase, HMN9, tryptophanyl-tRNA synthetase 1, WARS
Dynodwyr allanol	OMIM: 191050 HomoloGene: 3084 GeneCards: WARS1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • aminoacyl-tRNA ligase activity • nucleotide binding • ligase activity • GO:0001948, GO:0016582 protein binding • ATP binding • tryptophan-tRNA ligase activity • kinase inhibitor activity • protein kinase binding • protein domain specific binding • protein homodimerization activity Cydrannau o'r gell • extracellular exosome • cnewyllyn cell • cytoplasm • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • regulation of angiogenesis • protein biosynthesis • tRNA aminoacylation for protein translation • angiogenesis • negative regulation of cell population proliferation • tryptophanyl-tRNA aminoacylation • GO:0033128 negative regulation of protein phosphorylation • negative regulation of protein kinase activity • GO:1901313 positive regulation of gene expression • regulation of protein ADP-ribosylation • positive regulation of protein-containing complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7453	n/a
Ensembl	ENSG00000140105	n/a
UniProt	P23381	n/a
RefSeq (mRNA)	NM_004184 NM_173701 NM_213645 NM_213646	n/a
RefSeq (protein)	NP_004175 NP_776049 NP_998810 NP_998811	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn WARS yw WARS a elwir hefyd yn Tryptophan--tRNA ligase, cytoplasmic a Tryptophanyl-tRNA synthetase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q32.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn WARS.

• HMN9
• IFI53
• IFP53
• GAMMA-2

Llyfryddiaeth

• "A recurrent WARS mutation is a novel cause of autosomal dominant distal hereditary motor neuropathy. ". Brain. 2017. PMID 28369220.
• "Prediction of Recurrence and Survival for Triple-Negative Breast Cancer (TNBC) by a Protein Signature in Tissue Samples. ". Mol Cell Proteomics. 2015. PMID 26209610.
• "Increased TTS expression in patients with rheumatoid arthritis. ". Clin Exp Med. 2015. PMID 24515434.
• "Hypoxia signature of splice forms of tryptophanyl-tRNA synthetase marks pancreatic cancer cells with distinct metastatic abilities. ". Pancreas. 2011. PMID 21926542.
• "Effect of mini-tyrosyl-tRNA synthetase/mini-tryptophanyl-tRNA synthetase on ischemic angiogenesis in rats: proliferation and migration of endothelial cells.". Heart Vessels. 2011. PMID 20963594.