VPS36

VPS36
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HTH, 2ZME, 3CUQ
Dynodwyr
Cyfenwau	VPS36, C13orf9, EAP45, CGI-145, vacuolar protein sorting 36 homolog
Dynodwyr allanol	OMIM: 610903 HomoloGene: 9374 GeneCards: VPS36
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatidylinositol-3-phosphate binding • protein C-terminus binding • ubiquitin binding • GO:0001948, GO:0016582 protein binding • lipid binding Cydrannau o'r gell • cytoplasm • cytosol • late endosome • bilen • late endosome membrane • lysosome • extracellular exosome • cnewyllyn cell • endosome • ESCRT II complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • multivesicular body assembly • transcription, DNA-templated • endosomal transport • protein transport • protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • macroautophagy • GO:0015915 transport • endosome transport via multivesicular body sorting pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51028	n/a
Ensembl	ENSG00000136100	n/a
UniProt	Q86VN1	n/a
RefSeq (mRNA)	NM_016075 NM_001282168 NM_001282169	n/a
RefSeq (protein)	NP_001269097 NP_001269098 NP_057159	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VPS36 yw VPS36 a elwir hefyd yn Vacuolar protein sorting 36 homolog (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q14.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VPS36.

• EAP45
• C13orf9
• CGI-145

Llyfryddiaeth

• "Structural insight into the ESCRT-I/-II link and its role in MVB trafficking. ". EMBO J. 2007. PMID 17215868.
• "Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production. ". Retrovirology. 2015. PMID 26268989.
• "Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. ". Nat Struct Mol Biol. 2006. PMID 17057716.
• "RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells. ". Int J Oncol. 2017. PMID 28197629.
• "Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex.". Dev Cell. 2008. PMID 18539118.