VEGFC

VEGFC
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2X1W, 2X1X, 4BSK
Dynodwyr
Cyfenwau	VEGFC, Flt4-L, LMPH1D, VRP, vascular endothelial growth factor C, LMPHM4
Dynodwyr allanol	OMIM: 601528 HomoloGene: 3962 GeneCards: VEGFC
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • chemoattractant activity • GO:0001948, GO:0016582 protein binding • growth factor activity • vascular endothelial growth factor receptor 3 binding • vascular endothelial growth factor receptor binding Cydrannau o'r gell • extracellular region • bilen • platelet alpha granule lumen • extracellular space Prosesau biolegol • negative regulation of cell population proliferation • positive regulation of neuroblast proliferation • positive regulation of protein secretion • substrate-dependent cell migration • GO:0072468 signal transduction • positive regulation of protein autophosphorylation • multicellular organism development • morphogenesis of embryonic epithelium • positive regulation of cell-matrix adhesion • positive regulation of mast cell chemotaxis • positive regulation of blood vessel endothelial cell migration • positive regulation of cell division • induction of positive chemotaxis • platelet degranulation • positive regulation of peptidyl-tyrosine phosphorylation • negative regulation of blood pressure • positive regulation of cell population proliferation • positive regulation of lymphangiogenesis • regulation of vascular endothelial growth factor receptor signaling pathway • cell differentiation • positive regulation of epithelial cell proliferation • animal organ morphogenesis • positive chemotaxis • angiogenesis • response to hypoxia • positive regulation of endothelial cell proliferation • positive regulation of angiogenesis • cellular response to leukemia inhibitory factor • vascular endothelial growth factor receptor signaling pathway • regulation of signaling receptor activity • positive regulation of protein phosphorylation • sprouting angiogenesis • vascular endothelial growth factor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7424	n/a
Ensembl	ENSG00000150630	n/a
UniProt	P49767	n/a
RefSeq (mRNA)	NM_005429	n/a
RefSeq (protein)	NP_005420	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VEGFC yw VEGFC a elwir hefyd yn Vascular endothelial growth factor C (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q34.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VEGFC.

• VRP
• Flt4-L

Llyfryddiaeth

• "Immunohistochemical comparative analysis of lymphatic vessel density and VEGF-C expression in squamous cell carcinomas of the tongue between young and old patients. ". Pathol Res Pract. 2016. PMID 27876236.
• "Overexpression of VEGF-C correlates with a poor prognosis in esophageal cancer patients. ". Cancer Biomark. 2016. PMID 27540974.
• "Vascular endothelial growth factor-C ameliorates renal interstitial fibrosis through lymphangiogenesis in mouse unilateral ureteral obstruction. ". Lab Invest. 2017. PMID 29083411.
• "Serum VEGF-C levels as a candidate biomarker of hypervolemia in chronic kidney disease. ". Medicine (Baltimore). 2017. PMID 28471955.
• "The increased number of tumor-associated macrophage is associated with overexpression of VEGF-C, plays an important role in Kazakh ESCC invasion and metastasis.". Exp Mol Pathol. 2017. PMID 27939650.