VEGFB

VEGFB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2C7W, 2VWE, 2XAC
Dynodwyr
Cyfenwau	VEGFB, VEGFL, VRF, vascular endothelial growth factor B
Dynodwyr allanol	OMIM: 601398 HomoloGene: 87131 GeneCards: VEGFB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • heparin binding • protein homodimerization activity • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • chemoattractant activity • growth factor activity • vascular endothelial growth factor receptor 1 binding • vascular endothelial growth factor receptor 2 binding • vascular endothelial growth factor receptor 3 binding • vascular endothelial growth factor receptor binding Cydrannau o'r gell • bilen • intracellular anatomical structure • extracellular region • platelet alpha granule lumen • extracellular space Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of vascular endothelial growth factor receptor signaling pathway • positive regulation of protein kinase B signaling • cardiac muscle contraction • protein O-linked glycosylation • platelet degranulation • negative regulation of apoptotic process • coronary vasculature development • negative regulation of gene expression • heart development • positive regulation of vascular permeability • positive regulation of vascular wound healing • positive regulation of ERK1 and ERK2 cascade • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of cell division • positive chemotaxis • response to hypoxia • angiogenesis • positive regulation of endothelial cell proliferation • positive regulation of angiogenesis • vascular endothelial growth factor receptor signaling pathway • induction of positive chemotaxis • positive regulation of mast cell chemotaxis • regulation of signaling receptor activity • positive regulation of protein phosphorylation • sprouting angiogenesis • vascular endothelial growth factor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7423	n/a
Ensembl	ENSG00000173511	n/a
UniProt	P49765	n/a
RefSeq (mRNA)	NM_003377 NM_001243733	n/a
RefSeq (protein)	NP_001230662 NP_003368	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VEGFB yw VEGFB a elwir hefyd yn Vascular endothelial growth factor B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VEGFB.

• VRF
• VEGFL

Llyfryddiaeth

• "Vascular endothelial growth factor B coordinates metastasis of non-small cell lung cancer. ". Tumour Biol. 2015. PMID 25424698.
• "Clinical association of circulating VEGF-B levels with hyperlipidemia and target organ damage in type 2 diabetic patients. ". J Biol Regul Homeost Agents. 2014. PMID 25001655.
• "Vascular Endothelial Growth Factor-B Overexpressing Hearts Are Not Protected From Transplant-Associated Ischemia-Reperfusion Injury. ". Exp Clin Transplant. 2017. PMID 27588416.
• "Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment. ". Clin Endocrinol (Oxf). 2016. PMID 26387747.
• "Frameshift mutation of an angiogenesis factor VEGFB and its mutational heterogeneity in colorectal cancers.". Pathol Oncol Res. 2015. PMID 25633991.