VEGFA

VEGFA
Strwythurau
PDB	Human UniProt search: H0YBI8 PDBe H0YBI8 RCSB
Rhestr o ddynodwyr PDB
	1BJ1, 1CZ8, 1FLT, 1KAT, 1KMX, 1MJV, 1MKG, 1MKK, 1QTY, 1TZH, 1TZI, 1VGH, 1VPF, 1VPP, 2FJG, 2FJH, 2QR0, 2VGH, 2VPF, 3BDY, 3P9W, 3QTK, 3S1B, 3S1K, 3V2A, 4DEQ, 4GLN, 4GLS, 4KZN, 4QAF, 4WPB, 4ZFF, 5HHC, 5FV1, 5FV2, 5HHD, 5DN2
Dynodwyr
Cyfenwau	VEGFA, MVCD1, VEGF, VPF, vascular endothelial growth factor A
Dynodwyr allanol	OMIM: 192240 HomoloGene: 2534 GeneCards: VEGFA
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• heparin binding; • extracellular matrix binding; • cytokine activity; • growth factor activity; • neuropilin binding; • vascular endothelial growth factor receptor 2 binding; • receptor ligand activity; • vascular endothelial growth factor receptor 1 binding; • protein homodimerization activity; • platelet-derived growth factor receptor binding; • GO:0001948, GO:0016582 protein binding; • vascular endothelial growth factor receptor binding; • fibronectin binding; • chemoattractant activity; • identical protein binding; • protein heterodimerization activity;
Cydrannau o'r gell	• cytoplasm; • bilen; • extracellular region; • cell surface; • secretory granule; • platelet alpha granule lumen; • extracellular space; • GO:0005578 extracellular matrix;
Prosesau biolegol	• cardiac vascular smooth muscle cell development; • positive regulation of protein phosphorylation; • positive regulation of MAP kinase activity; • vascular endothelial growth factor signaling pathway; • positive regulation of receptor internalization; • outflow tract morphogenesis; • mammary gland alveolus development; • monocyte differentiation; • cell migration involved in sprouting angiogenesis; • vasculogenesis; • positive regulation of retinal ganglion cell axon guidance; • vascular endothelial growth factor receptor signaling pathway; • positive regulation of vascular permeability; • positive regulation of mesenchymal cell proliferation; • angiogenesis; • positive regulation of blood vessel endothelial cell migration; • positive regulation of ERK1 and ERK2 cascade; • mesoderm development; • positive regulation of positive chemotaxis; • positive regulation of p38MAPK cascade; • positive regulation of neuroblast proliferation; • dopaminergic neuron differentiation; • positive regulation of branching involved in ureteric bud morphogenesis; • kidney development; • lung development; • coronary artery morphogenesis; • in utero embryonic development; • cell maturation; • commissural neuron axon guidance; • positive regulation of peptidyl-serine phosphorylation; • positive regulation of CREB transcription factor activity; • basophil chemotaxis; • artery morphogenesis; • regulation of transcription from RNA polymerase II promoter in response to hypoxia; • positive regulation of peptidyl-tyrosine autophosphorylation; • positive regulation of peptidyl-tyrosine phosphorylation; • branching involved in blood vessel morphogenesis; • positive regulation of protein localization to early endosome; • primitive erythrocyte differentiation; • positive regulation of protein kinase D signaling; • lactation; • cell differentiation; • epithelial cell differentiation; • positive regulation of leukocyte migration; • positive regulation of epithelial cell proliferation; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • nervous system development; • macrophage differentiation; • positive regulation of angiogenesis; • regulation of retinal ganglion cell axon guidance; • lymph vessel morphogenesis; • post-embryonic camera-type eye development; • regulation of cell shape; • ovarian follicle development; • branching morphogenesis of an epithelial tube; • coronary vein morphogenesis; • surfactant homeostasis; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • response to hypoxia; • positive regulation of endothelial cell proliferation; • positive regulation of protein-containing complex assembly; • positive regulation of protein kinase C signaling; • positive regulation of cell migration; • heart morphogenesis; • platelet degranulation; • positive regulation of axon extension involved in axon guidance; • positive regulation of endothelial cell migration; • multicellular organism development; • positive regulation of histone deacetylase activity; • tube formation; • GO:1901313 positive regulation of gene expression; • positive regulation of protein autophosphorylation; • endothelial cell chemotaxis; • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; • eye photoreceptor cell development; • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; • positive regulation of focal adhesion assembly; • cellular response to vascular endothelial growth factor stimulus; • activation of protein kinase activity; • positive regulation of cell division; • camera-type eye morphogenesis; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of cell adhesion; • cellular response to hypoxia; • positive chemotaxis; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • positive regulation of cell population proliferation; • induction of positive chemotaxis; • positive regulation of mast cell chemotaxis; • motor neuron migration; • positive regulation of tyrosine phosphorylation of STAT protein; • growth; • VEGF-activated neuropilin signaling pathway; • positive regulation of phosphorylation; • regulation of signaling receptor activity; • negative regulation of gene expression; • cytokine-mediated signaling pathway; • positive regulation of cell migration involved in sprouting angiogenesis; • cellular stress response to acid chemical; • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; • positive regulation of sprouting angiogenesis; • positive regulation of DNA biosynthetic process; • sprouting angiogenesis; • regulation of nitric oxide mediated signal transduction; • positive regulation of cold-induced thermogenesis; • GO:0072468 signal transduction;
	Sources:Amigo / QuickGO
Orthologau
	7422
	n/a
	ENSG00000112715
	n/a
	P15692
	n/a
NM_003376; NM_001025366; NM_001025367; NM_001025368; NM_001025369;
	NM_001025370; NM_001033756; NM_001171622; NM_001171623; NM_001171624; NM_001171625; NM_001171626; NM_001171627; NM_001171628; NM_001171629; NM_001171630; NM_001204384; NM_001204385; NM_001287044; NM_001317010
	n/a
NP_001020537; NP_001020538; NP_001020539; NP_001020540; NP_001020541;
	NP_001028928; NP_001165093; NP_001165094; NP_001165095; NP_001165096; NP_001165097; NP_001165098; NP_001165099; NP_001165100; NP_001165101; NP_001191313; NP_001191314; NP_001273973; NP_001303939; NP_003367
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VEGFA yw VEGFA a elwir hefyd yn Vascular endothelial growth factor A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.1.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VEGFA.

VPF
VEGF
MVCD1

Llyfryddiaeth[golygu | golygu cod]

"Photocoagulation of the Retinal Nonperfusion Area Prevents the Expression of the Vascular Endothelial Growth Factor in an Animal Model. ". Invest Ophthalmol Vis Sci. 2017. PMID 29098298.
"Upregulation of vascular endothelial growth factor (VEGF), its role in progression and prognosis of non-small cell lung carcinoma. ". Cancer Genet. 2017. PMID 29025597.
"[Expression of vascular endothelial growth factor (VEGF) in uterine tissues as one of the mechanisms of algogenezis in adenomyosis, associated with chronic pelvic pain]. ". Patol Fiziol Eksp Ter. 2016. PMID 29215242.
"AAV-CRISPR/Cas9-Mediated Depletion of VEGFR2 Blocks Angiogenesis In Vitro. ". Invest Ophthalmol Vis Sci. 2017. PMID 29204648.
"Functional Characterization of VEGF- and FGF-induced Tumor Blood Vessel Models in Human Cancer Xenografts.". Anticancer Res. 2017. PMID 29187438.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] VEGFA - Cronfa NCBI

[1]

[2]