VCP

VCP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3EBB, 3HU1, 3HU2, 3HU3, 3QC8, 3QQ7, 3QQ8, 3QWZ, 3TIW, 4KDI, 4KDL, 4KLN, 4KO8, 4KOD, 4P0A, 5C19, 3CF2, 3CF1, 5FTK, 5C18, 3CF3, 5FTJ, 5FTM, 5FTL, 5FTN, 5C1B, 5C1A, 5DYI, 5DYG
Dynodwyr
Cyfenwau	VCP, ALS14, HEL-220, HEL-S-70, IBMPFD, IBMPFD1, TERA, p97, Valosin-containing protein, CMT2Y, valosin containing protein, CDC48, FTDALS6
Dynodwyr allanol	OMIM: 601023 HomoloGene: 5168 GeneCards: VCP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein domain specific binding • GO:0032403 protein-containing complex binding • ADP binding • K48-linked polyubiquitin modification-dependent protein binding • polyubiquitin modification-dependent protein binding • GO:0001948, GO:0016582 protein binding • ubiquitin-like protein ligase binding • ubiquitin-specific protease binding • MHC class I protein binding • protein phosphatase binding • deubiquitinase activator activity • signaling receptor binding • hydrolase activity • ATP binding • ubiquitin protein ligase binding • lipid binding • identical protein binding • ATPase activity • RNA binding • BAT3 complex binding Cydrannau o'r gell • site of double-strand break • cytosol • intracellular membrane-bounded organelle • myelin sheath • lipid droplet • nucleoplasm • VCP-NSFL1C complex • Reticwlwm endoplasmig • Derlin-1 retrotranslocation complex • VCP-NPL4-UFD1 AAA ATPase complex • perinuclear region of cytoplasm • proteasome complex • cnewyllyn cell • extracellular exosome • extracellular region • secretory granule lumen • azurophil granule lumen • ficolin-1-rich granule lumen • ATPase complex • endoplasmic reticulum membrane • cytoplasm • cytoplasmic stress granule • GO:0009327 protein-containing complex • synapse • glutamatergic synapse Prosesau biolegol • regulation of aerobic respiration • regulation of apoptotic process • GO:1903364 positive regulation of protein catabolic process • positive regulation of protein-containing complex assembly • ubiquitin-dependent protein catabolic process • positive regulation of Lys63-specific deubiquitinase activity • establishment of protein localization • error-free translesion synthesis • viral genome replication • positive regulation of oxidative phosphorylation • ER-associated misfolded protein catabolic process • protein N-linked glycosylation via asparagine • cellular response to DNA damage stimulus • positive regulation of ATP biosynthetic process • endoplasmic reticulum to Golgi vesicle-mediated transport • ATP metabolic process • retrograde protein transport, ER to cytosol • NADH metabolic process • positive regulation of protein K63-linked deubiquitination • double-strand break repair • ubiquitin-dependent ERAD pathway • positive regulation of mitochondrial membrane potential • activation of cysteine-type endopeptidase activity involved in apoptotic process • protein homooligomerization • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • protein hexamerization • aggresome assembly • flavin adenine dinucleotide catabolic process • proteasome-mediated ubiquitin-dependent protein catabolic process • autophagy • GO:0100026 DNA repair • ERAD pathway • positive regulation of ubiquitin-specific protease activity • GO:0000046 autophagosome maturation • translesion synthesis • protein folding • protein methylation • protein deubiquitination • neutrophil degranulation • transmembrane transport • proteasomal protein catabolic process • protein ubiquitination • endoplasmic reticulum unfolded protein response • endoplasmic reticulum stress-induced pre-emptive quality control • macroautophagy • endosome to lysosome transport via multivesicular body sorting pathway • GO:0015915 transport • cellular response to heat • stress granule disassembly • GO:1904739 regulation of synapse organization • mitotic spindle disassembly • positive regulation of canonical Wnt signaling pathway • cellular response to arsenite ion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7415	n/a
Ensembl	ENSG00000165280	n/a
UniProt	P55072	n/a
RefSeq (mRNA)	NM_007126 NM_001354927 NM_001354928	n/a
RefSeq (protein)	NP_009057 NP_001341856 NP_001341857	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VCP yw VCP a elwir hefyd yn Transitional endoplasmic reticulum ATPase a Valosin containing protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VCP.

• p97
• TERA
• CDC48

Llyfryddiaeth

• "Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97. ". Cell Death Dis. 2015. PMID 26720340.
• "Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis. ". Cancer Cell. 2015. PMID 26555175.
• "The AAA+ ATPase p97, a cellular multitool. ". Biochem J. 2017. PMID 28819009.
• "The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication. ". PLoS Pathog. 2017. PMID 28494016.
• "Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons.". J Biol Chem. 2017. PMID 28360103.