VAV3

VAV3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D86
Dynodwyr
Cyfenwau	VAV3, vav guanine nucleotide exchange factor 3
Dynodwyr allanol	OMIM: 605541 HomoloGene: 38143 GeneCards: VAV3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • metal ion binding • epidermal growth factor receptor binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • guanyl-nucleotide exchange factor activity Cydrannau o'r gell • cytoplasm • cytosol • Cellbilen Prosesau biolegol • angiogenesis • Fc-gamma receptor signaling pathway involved in phagocytosis • GO:0007243 intracellular signal transduction • ephrin receptor signaling pathway • lamellipodium assembly • regulation of Rho protein signal transduction • positive regulation of phosphatidylinositol 3-kinase activity • vascular endothelial growth factor receptor signaling pathway • small GTPase mediated signal transduction • B cell receptor signaling pathway • cell projection assembly • Fc-epsilon receptor signaling pathway • positive regulation of apoptotic process • integrin-mediated signaling pathway • cellular response to DNA damage stimulus • regulation of cell size • regulation of small GTPase mediated signal transduction • cell migration • platelet activation • vesicle fusion • positive regulation of cell adhesion • positive regulation of B cell proliferation • neutrophil chemotaxis • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • positive regulation of signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10451	n/a
Ensembl	ENSG00000134215	n/a
UniProt	Q9UKW4	n/a
RefSeq (mRNA)	NM_001079874 NM_006113	n/a
RefSeq (protein)	NP_001073343 NP_006104	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VAV3 yw VAV3 a elwir hefyd yn Vav guanine nucleotide exchange factor 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p13.3.

Llyfryddiaeth

• "VAV3 oncogene expression in colorectal cancer: clinical aspects and functional characterization. ". Sci Rep. 2015. PMID 25791293.
• "VAV3 Overexpressed in Cancer Stem Cells Is a Poor Prognostic Indicator in Ovarian Cancer Patients. ". Stem Cells Dev. 2015. PMID 25715123.
• "Vav3 is linked to poor prognosis of pancreatic cancers and promotes the motility and invasiveness of pancreatic cancer cells. ". Pancreatology. 2016. PMID 27453460.
• "VAV3 Gene Polymorphism Is Associated with Paget's Disease of Bone. ". Genet Test Mol Biomarkers. 2016. PMID 27172236.
• "Differential Gene Expression of the Proto-oncogene VAV3 and the Transcript Variant VAV3.1 in Oral Squamous Cell Carcinoma.". Anticancer Res. 2015. PMID 25964534.