VAV2

VAV2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ
Dynodwyr
Cyfenwau	VAV2, VAV-2, vav guanine nucleotide exchange factor 2
Dynodwyr allanol	OMIM: 600428 HomoloGene: 2530 GeneCards: VAV2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • guanyl-nucleotide exchange factor activity • epidermal growth factor receptor binding • metal ion binding • GO:0001948, GO:0016582 protein binding • phosphotyrosine residue binding Cydrannau o'r gell • cytoplasm • cytosol • Cellbilen Prosesau biolegol • regulation of cell size • GO:0007243 intracellular signal transduction • Fc-gamma receptor signaling pathway involved in phagocytosis • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • ephrin receptor signaling pathway • positive regulation of phosphatidylinositol 3-kinase activity • platelet activation • Fc-epsilon receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • cell projection assembly • angiogenesis • positive regulation of apoptotic process • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • cell migration • GO:0072468 signal transduction • lamellipodium assembly • small GTPase mediated signal transduction • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7410	n/a
Ensembl	ENSG00000160293	n/a
UniProt	P52735	n/a
RefSeq (mRNA)	NM_001134398 NM_003371	n/a
RefSeq (protein)	NP_001127870 NP_003362	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VAV2 yw VAV2 a elwir hefyd yn Vav guanine nucleotide exchange factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q34.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VAV2.

• VAV-2

Llyfryddiaeth

• "Guanine exchange factor Vav2: a novel potential target for the development of drugs effective in the prevention of papillomavirus infection and disease. ". Am J Ther. 2009. PMID 19451809.
• "Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. ". Mol Cell Biol. 2000. PMID 10982832.
• "Upregulated Vav2 in gastric cancer tissues promotes tumor invasion and metastasis. ". Tumour Biol. 2017. PMID 28459214.
• "Potassium-chloride cotransporter 3 interacts with Vav2 to synchronize the cell volume decrease response with cell protrusion dynamics. ". PLoS One. 2013. PMID 23724134.
• "Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo.". Mol Cell Neurosci. 2010. PMID 20298788.