VAV1 Dynodwyr Cyfenwau VAV1 Dynodwyr allanol OMIM: 164875 HomoloGene: 3961 GeneCards: VAV1 Ontoleg y genyn Gweithrediad moleciwlaidd • guanyl-nucleotide exchange factor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • metal ion binding • GO:0001948, GO:0016582 protein binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • phosphotyrosine residue binding Cydrannau o'r gell • cytosol • cell-cell junction • Cellbilen Prosesau biolegol • regulation of cell size • GO:0007243 intracellular signal transduction • Fc-gamma receptor signaling pathway involved in phagocytosis • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • T cell costimulation • neutrophil chemotaxis • reactive oxygen species metabolic process • platelet activation • Fc-epsilon receptor signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • T cell differentiation • vascular endothelial growth factor receptor signaling pathway • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • ffagocytosis • positive regulation of apoptotic process • integrin-mediated signaling pathway • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of natural killer cell mediated cytotoxicity • T cell activation • positive regulation of cell adhesion • GO:0009373 regulation of transcription, DNA-templated • phosphatidylinositol phosphate biosynthetic process • small GTPase mediated signal transduction • G protein-coupled receptor signaling pathway • positive regulation of protein kinase B signaling • cytokine-mediated signaling pathway • positive regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn VAV1 yw VAV1 a elwir hefyd yn Vav guanine nucleotide exchange factor 1 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VAV1.
"Estrogen induces Vav1 expression in human breast cancer cells. ". PLoS One . 2014. PMID 24905577 . "Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in leukemia T cells. ". Cell Signal . 2014. PMID 24880064 . "Vav1 expression is increased in esophageal squamous cell carcinoma and indicates poor prognosis. ". Biochem Biophys Res Commun . 2017. PMID 28336434 . "VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis. ". Genes Immun . 2017. PMID 28053322 . "Mutation of Vav1 adaptor region reveals a new oncogenic activation. ". Oncotarget . 2015. PMID 25426554 . 
