UNG

UNG
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AKZ, 1DPU, 1EMH, 1EMJ, 1Q3F, 1SSP, 1UGH, 1YUO, 2HXM, 2OXM, 2OYT, 2SSP, 3FCF, 3FCI, 3FCK, 3FCL, 3TKB, 4SKN, 5AYR
Dynodwyr
Cyfenwau	UNG, DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2, uracil DNA glycosylase
Dynodwyr allanol	OMIM: 191525 HomoloGene: 6585 GeneCards: UNG
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • damaged DNA binding • GO:0001948, GO:0016582 protein binding • hydrolase activity • hydrolase activity, hydrolyzing N-glycosyl compounds • ribosomal small subunit binding • uracil DNA N-glycosylase activity Cydrannau o'r gell • cnewyllyn cell • mitocondria • nucleoplasm Prosesau biolegol • positive regulation of isotype switching • somatic hypermutation of immunoglobulin genes • GO:0022415 viral process • negative regulation of apoptotic process • depyrimidination • GO:0100026 DNA repair • somatic recombination of immunoglobulin gene segments • cellular response to DNA damage stimulus • base-excision repair, AP site formation via deaminated base removal • base-excision repair • isotype switching Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7374	n/a
Ensembl	ENSG00000076248	n/a
UniProt	P13051	n/a
RefSeq (mRNA)	NM_080911 NM_003362	n/a
RefSeq (protein)	NP_003353 NP_550433	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UNG yw UNG a elwir hefyd yn Uracil DNA glycosylase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q24.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UNG.

• DGU
• UDG
• UNG1
• UNG2
• HIGM4
• HIGM5
• UNG15

Llyfryddiaeth

• "Electrostatic properties of complexes along a DNA glycosylase damage search pathway. ". Biochemistry. 2014. PMID 25408964.
• "Uracil-DNA glycosylase (UNG) rs246079 G/A polymorphism is associated with decreased risk of esophageal cancer in a Chinese population. ". Med Oncol. 2014. PMID 25301111.
• "Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells. ". Nucleic Acids Res. 2017. PMID 29036472.
• "Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation. ". ACS Chem Biol. 2017. PMID 28787572.
• "[Over-expression of uracil DNA glycosylase 2 (UNG2) enhances the resistance to oxidative damage in HepG2 cells].". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017. PMID 28395718.