UNC45A

UNC45A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DBA
Dynodwyr
Cyfenwau	UNC45A, GC-UNC45, GCUNC-45, GCUNC45, IRO039700, SMAP-1, SMAP1, UNC-45A, unc-45 myosin chaperone A, OOHE
Dynodwyr allanol	OMIM: 611219 HomoloGene: 32423 GeneCards: UNC45A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • Hsp90 protein binding • GO:0001948, GO:0016582 protein binding • cadherin binding Cydrannau o'r gell • cytoplasm • perinuclear region of cytoplasm • cnewyllyn cell • Golgi apparatus • cytosol • nuclear speck Prosesau biolegol • multicellular organism development • cell differentiation • muscle organ development • chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	55898	n/a
Ensembl	ENSG00000140553	n/a
UniProt	Q9H3U1	n/a
RefSeq (mRNA)	NM_001039675 NM_017979 NM_018671 NM_001323619 NM_001323620 NM_001323621	n/a
RefSeq (protein)	NP_001034764 NP_001310548 NP_001310549 NP_001310550 NP_061141	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UNC45A yw UNC45A a elwir hefyd yn Unc-45 myosin chaperone A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q26.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UNC45A.

• SMAP1
• SMAP-1
• GCUNC45
• UNC-45A
• GC-UNC45
• GCUNC-45
• IRO039700

Llyfryddiaeth

• "Differential turnover of myosin chaperone UNC-45A isoforms increases in metastatic human breast cancer. ". J Mol Biol. 2011. PMID 21802425.
• "Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility. ". Am J Pathol. 2007. PMID 17872978.
• "UNC-45a promotes myosin folding and stress fiber assembly. ". J Cell Biol. 2017. PMID 29055011.
• "UNC-45A is required for neurite extension via controlling NMII activation. ". Mol Biol Cell. 2017. PMID 28356421.
• "UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion.". J Immunol. 2015. PMID 26438524.