UCHL5

UCHL5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3A7S, 3IHR, 3RII, 3RIS, 3TB3, 4UEL, 4UEM, 4UF5, 4UF6, 4WLP
Dynodwyr
Cyfenwau	UCHL5, CGI-70, INO80R, UCH-L5, UCH37, Ubiquitin carboxyl-terminal hydrolase L5, ubiquitin C-terminal hydrolase L5
Dynodwyr allanol	OMIM: 610667 HomoloGene: 9326 GeneCards: UCHL5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cysteine-type peptidase activity • thiol-dependent deubiquitinase • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • endopeptidase inhibitor activity • hydrolase activity • RNA binding • proteasome binding Cydrannau o'r gell • cytoplasm • intracellular anatomical structure • proteasome complex • cnewyllyn cell • cytosolic proteasome complex • nucleoplasm • mitocondria • cytosol • Ino80 complex Prosesau biolegol • regulation of proteasomal protein catabolic process • DNA recombination • GO:0009373 regulation of transcription, DNA-templated • lateral ventricle development • ubiquitin-dependent protein catabolic process • transcription, DNA-templated • proteolysis • cellular response to DNA damage stimulus • forebrain morphogenesis • GO:0100026 DNA repair • midbrain development • negative regulation of endopeptidase activity • protein deubiquitination • negative regulation of proteasomal ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51377	n/a
Ensembl	ENSG00000116750	n/a
UniProt	Q9Y5K5 Q5LJB0	n/a
RefSeq (mRNA)	NM_001199261 NM_001199262 NM_001199263 NM_015984 NM_001350840 NM_001350841 NM_001350842 NM_001350843 NM_001350844 NM_001350845 NM_001350846 NM_001350847 NM_001350848 NM_001350849 NM_001350850 NM_001350851 NM_001350852	n/a
RefSeq (protein)	NP_001186190 NP_001186191 NP_001186192 NP_057068 NP_001337769 NP_001337770 NP_001337771 NP_001337772 NP_001337773 NP_001337774 NP_001337775 NP_001337776 NP_001337777 NP_001337778 NP_001337779 NP_001337780 NP_001337781	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UCHL5 yw UCHL5 a elwir hefyd yn Ubiquitin carboxyl-terminal hydrolase ac Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q31.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UCHL5.

• UCH37
• CGI-70
• INO80R
• UCH-L5

Llyfryddiaeth

• "Expression and clinical significance of UCH37 in human esophageal squamous cell carcinoma. ". Dig Dis Sci. 2012. PMID 22615012.
• "Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme. ". FEBS J. 2011. PMID 21995438.
• "UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer. ". Tumour Biol. 2017. PMID 28681694.
• "Nuclear ubiquitin C-terminal hydrolase L5 expression associates with increased patient survival in pancreatic ductal adenocarcinoma. ". Tumour Biol. 2017. PMID 28653876.
• "High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer.". Tumour Biol. 2014. PMID 25123264.