UCHL1

UCHL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4JKJ, 2ETL, 2LEN, 3IFW, 3IRT, 3KVF, 3KW5, 4DM9
Dynodwyr
Cyfenwau	UCHL1, HEL-117, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, Uch-L1, HEL-S-53, ubiquitin C-terminal hydrolase L1, SPG79, UCHL-1
Dynodwyr allanol	OMIM: 191342 HomoloGene: 37894 GeneCards: UCHL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cysteine-type peptidase activity • GO:0070122 peptidase activity • ligase activity • ubiquitin binding • GO:0001948, GO:0016582 protein binding • alpha-2A adrenergic receptor binding • omega peptidase activity • cysteine-type endopeptidase activity • hydrolase activity • ubiquitin protein ligase binding • thiol-dependent deubiquitinase Cydrannau o'r gell • cytoplasm • bilen • endoplasmic reticulum membrane • myelin sheath • Cellbilen • intracellular anatomical structure • nucleoplasm • axon • neuronal cell body • Reticwlwm endoplasmig • neuron projection terminus • axon cytoplasm • cytosol Prosesau biolegol • axon target recognition • eating behavior • axonogenesis • ubiquitin-dependent protein catabolic process • proteolysis • axonal transport of mitochondrion • response to ischemia • neuromuscular process • negative regulation of MAP kinase activity • sensory perception of pain • cell population proliferation • regulation of macroautophagy • adult walking behavior • proteasome-mediated ubiquitin-dependent protein catabolic process • protein deubiquitination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7345	n/a
Ensembl	ENSG00000154277	n/a
UniProt	P09936	n/a
RefSeq (mRNA)	NM_004181	n/a
RefSeq (protein)	NP_004172	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UCHL1 yw UCHL1 a elwir hefyd yn Ubiquitin C-terminal hydrolase L1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4p13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UCHL1.

• NDGOA
• PARK5
• PGP95
• SPG79
• PGP9.5
• Uch-L1
• HEL-117
• PGP*9.5
• HEL-S-53

Llyfryddiaeth

• "Decreased UCHL1 expression as a cytologic biomarker for aggressive behavior in pancreatic neuroendocrine tumors. ". Surgery. 2018. PMID 29150024.
• "Investigation of UCH-L1 levels in ischemic stroke, intracranial hemorrhage and metabolic disorder induced impaired consciousness. ". Am J Emerg Med. 2017. PMID 28651886.
• "Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma. ". PLoS One. 2017. PMID 28472177.
• "Novel UCHL1 mutations reveal new insights into ubiquitin processing. ". Hum Mol Genet. 2017. PMID 28007905.
• "Characterization of the Folding of a 52-Knotted Protein Using Engineered Single-Tryptophan Variants.". Biophys J. 2016. PMID 28002735.