UBR2

UBR2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3NY2, 3NY3
Dynodwyr
Cyfenwau	UBR2, C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3, ubiquitin protein ligase E3 component n-recognin 2
Dynodwyr allanol	OMIM: 609134 HomoloGene: 26151 GeneCards: UBR2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • zinc ion binding • leucine binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • metal ion binding • GO:0050372 ubiquitin-protein transferase activity • transferase activity Cydrannau o'r gell • chromatin • cnewyllyn cell • ubiquitin ligase complex • cytoplasm • cytosol Prosesau biolegol • cellular response to leucine • GO:0044257 protein catabolic process • male meiosis I • ubiquitin-dependent protein catabolic process • protein ubiquitination • ubiquitin-dependent protein catabolic process via the N-end rule pathway • negative regulation of TOR signaling • histone H2A ubiquitination • protein polyubiquitination • reciprocal meiotic recombination • male meiotic nuclear division • spermatogenesis • negative regulation of transposition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23304	n/a
Ensembl	ENSG00000024048	n/a
UniProt	Q8IWV8	n/a
RefSeq (mRNA)	NM_001184801 NM_015255 NM_001363705	n/a
RefSeq (protein)	NP_001171730 NP_056070 NP_001350634	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBR2 yw UBR2 a elwir hefyd yn Ubiquitin protein ligase E3 component n-recognin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBR2.

• C6orf133
• bA49A4.1
• dJ242G1.1
• dJ392M17.3

Llyfryddiaeth

• "RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. ". Hum Mol Genet. 2004. PMID 15317757.
• "UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells. ". PLoS One. 2012. PMID 22616001.
• "Association of single nucleotide polymorphisms in UBR2 gene with idiopathic aspermia or oligospermia in Sichuan, China. ". Andrologia. 2016. PMID 26940145.
• "Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest. ". J Assist Reprod Genet. 2011. PMID 21573678.
• "Identification of a novel antibody associated with autoimmune pancreatitis.". N Engl J Med. 2009. PMID 19940298.